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CPC Scientific Z-Ile-Glu(OtBu)-Ala-Leu-CHO 0.5MG
Supplier: CPC Scientific CASP087A
Inhibitor of chymotrypsin-like activity of the multicatalytic proteinase complex (MPC; 20S proteasome) in HT4 cells. This peptide is also the first inhibitor reported so far inducing the accumulation of ubiquitinylated proteins in neuronal cells. Furthermore, this peptide's aldehyde component can cause massive apoptosis in murine leukemia L1210 cells. Therefore, proteasome inhibitors can be regarded as potential anti-neoplastic agents. ONE-LETTER SEQUENCE: Z-I-Glu(OtBu)-AL-CHOMOLECULAR FORMULA: C32H50N4O8MOLECULAR WEIGHT:618.77STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [158442-41-2], SYNONYMS: Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde, Z-Ile-Glu(OtBu)-Ala-L-leucinal, Proteasome Inhibitor I, PSIRESEARCH AREA: Apoptosis
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