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Apexbio Technology LLC Z-LEHD-FMK(Synonyms: LEHD-FMK, Z-LEHD(OMe)-FMK, Caspase-9 inhibitor I), 1mg, CAS: 210345-04-3.
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Supplier:  Apexbio Technology LLC B32331

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Z-LEHD-FMK (CAS 210345-04-3) is a selective irreversible inhibitor targeting caspase-9 an initiator caspase critical to mitochondria-mediated apoptosis Caspase-9 activation leads to downstream cleavage of procaspase-3 and procaspase-7 Experimentally Z-LEHD-FMK inhibits TRAIL-induced apoptosis in models including human colon cancer cells (HCT116) kidney cells (HEK293) and normal hepatocytes suggesting selective cytoprotection of normal tissues Additionally in vivo studies demonstrate neuroprotection as indicated by improved neurological outcomes following ischemia/reperfusion injury and spinal cord trauma

Catalog No. 50-000-60367


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