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Medchemexpress LLC Z-VAD(OMe)-FMK | 187389-52-2 | 98.0% | 467.49 | 100 MG
Supplier: Medchemexpress LLC HY16658100MG
Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor. It also acts as an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor, irreversibly modifying UCHL1 by targeting its active site.
- Inhibits intracellular activation of caspase-like proteases
- Suppresses caspase-3 activity
- Effectively inhibits UCHL1's reaction with HA-UbVME
- Blocks cell death induced by SMN deficiency
- Prolongs survival rate in mice injected with LPS
- Reduces early brain injury after subarachnoid hemorrhage
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