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Medchemexpress LLC Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) | 187389-52-2 | 467.49 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY1665810MM/1ML

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Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor. It also acts as an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor, modifying UCHL1 by targeting its active site. This broad-spectrum caspase inhibitor has been shown to inhibit the intracellular activation of caspase-like proteases, offering neurovascular protection and improving neurological outcomes in various studies.

  • Cell-permeable and irreversible pan-caspase inhibitor
  • Inhibits ubiquitin carboxy-terminal hydrolase L1 (UCHL1)
  • Suppresses caspase-3 activity in lung tissues
  • Decreases caspase-3 activation and reduces blood-brain barrier permeability
  • Relieves vasospasm and abolishes brain edema
  • Blocks cell death induced by SMN deficiency
  • Significantly prolongs survival rate in mice after LPS injection

Catalog No. 50-003-91535


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