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Apexbio Technology LLC Z-VDVAD-FMK 210344-92-6 10mg
Supplier: Apexbio Technology LLC A192210
Z-VDVAD-FMK (CAS 210344-92-6) is an irreversible cell-permeable inhibitor primarily targeting caspase-2 with additional inhibitory effects on caspases-3 and -7 It functions by binding covalently to the active site of caspase enzymes thereby interrupting downstream apoptotic signaling processes In cellular studies treatment with Z-VDVAD-FMK suppresses caspase-2-dependent cytochrome c release triggered by apoptotic inducers such as etoposide Moreover Z-VDVAD-FMK effectively reduces apoptosis-related responses including cellular detachment DNA fragmentation and cleavage of PARP2 in endothelial cells exposed to oxyhemoglobin This small molecule serves as a pivotal tool for dissecting caspase pathways and investigating apoptosis-mediated cellular outcomes in biomedical research
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