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Apexbio Technology LLC Z-VEID-FMK 210344-96-0 10mg
Supplier: Apexbio Technology LLC A192310
Z-VEID-FMK is a cell-permeable irreversible inhibitor primarily targeting caspase-6 a cysteine protease involved in apoptosis regulation This peptide-based fluoromethyl ketone derivative specifically binds to the active site of caspase-6 blocking the proteolytic cleavage events mediated by this enzyme In apoptosis signaling caspase-6 activation contributes to downstream cleavage of multiple cellular substrates including lamins and nuclear proteins In various experimental models Z-VEID-FMK has been employed to dissect caspase-6-dependent apoptotic pathways and to analyze caspase-specific roles in neuronal and immune cell apoptosis induced by stimuli such as TNF or Fas ligand
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