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Medchemexpress LLC ZCL278 | 587841-73-4 | 98.5% | 584.89 | 50 MG
Supplier: Medchemexpress LLC HY1396350MG
ZCL278 is a selective Cdc42 inhibitor with Kds of 6.4 μM in fluorescence titration and 11.4 μM in surface plasmon resonance (SPR) measurement. It can disrupt the Cdc42-ITSN interaction and GTP/GDP binding. ZCL278 shows inhibitory effects on various enveloped viruses but is ineffective against non-enveloped viruses. It is also used in studies of arsenic neurotoxicity and HER2-positive gastric cancer (GC).
- Impedes wound healing in PC-3 cells
- Inhibits Cdc42 activity in PC-3 cells
- Inhibits mice primary neurons branching and growth cone motility
- Prevents release of Junin virus (JUNV) ribonucleoprotein cores
- Inhibits VSV, LCMV, and DV2 infections
- Improves cytotoxicity of NaAsO2 in rat astrocytes
- Reduces cholesterol levels and reverses collateral resistance in TC cells
- Inhibits JUNV replication in a mouse model
- Reduces cholesterol enrichment and reverses collateral resistance in vivo
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