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Medchemexpress LLC Α-Zearalenol | 36455-72-8 | 5 MG
Supplier: Medchemexpress LLC HYN67105MG
Alpha-Zearalenol is a mycotoxin that exhibits high affinity for estrogen receptors (ER). This derivative of zearalenone (ZEN) is known to induce reproductive disorders in animals through its xenoestrogenic effects and is intended for research use only.
- Cytotoxicity in KB cells with an IC50 of 100.29 μM.
- Cytotoxicity in Vero cells with an IC50 of 60.33 μM.
- In MCF-7 cells, it shows an IC50 of 12.5 μM and increases cell viability and population in S and G2/M phases.
- Slightly cytotoxic to MDA-MB231 cells, with no visible change in cell cycle phases.
- Reduces TNF-α expression in HepG2 cells; combined with β-ZOL, it acts antagonistically for IL-1β and synergistically for IL-8 at higher concentrations.
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