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Medchemexpress LLC Zidesamtinib | 2739829-00-4 | C22H22FN7O | 50 MG
Supplier: Medchemexpress LLC HY15229250MG
Zidesamtinib (NVL-520) is a potent, selective, orally active, and brain-penetrant inhibitor of diverse ROS1 fusions and resistance mutations, with IC50s of 0.7 and 7.9 nM for wild-type ROS1 and ROS1 G2032R, respectively. It spares TRK inhibition and can be used for cancer research.
- Potent, selective, orally active, and brain-penetrant inhibitor
- Inhibits diverse ROS1 fusions and resistance mutations
- Spares TRK inhibition
- Suitable for cancer research
- Purity of 99.78%
- Molecular weight: 419.45
- Solid, off-white to light yellow appearance
- Inhibits wild-type ROS1 fusions with average IC50s of 0.4 nM
- Inhibits ROS1 fusions with G2032R mutation with average IC50s of 1.6 nM
- Potently inhibits non-G2032R ROS1 mutants with IC50s ≤ 1.5 nM
- Induces tumor regression in wild-type ROS1 xenograft models
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