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Apexbio Technology LLC Zileuton 111406-87-2 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A53845.1
Zileuton (CAS 111406-87-2) is a pharmacological inhibitor targeting the enzyme 5-lipoxygenase (5-LOX) It inhibits conversion of arachidonic acid to leukotriene precursors thereby attenuating formation of inflammatory leukotrienes (LTB4 LTC4 LTD4 LTE4) In rat leukocyte and basophilic leukemia assays Zileuton exhibits inhibition with reported IC50 values of 0 3 M and 0 5 M respectively Research demonstrates that Zileuton induces COX-2 expression and PGE2 synthesis via PKC -dependent activation of ERK1/2 and Akt suggesting cardioprotective potential against ischemia/reperfusion injury Additionally animal models indicate neuroprotective benefits by mitigating inflammatory responses after cerebral ischemia Clinically Zileuton is utilized for asthma management targeting leukotriene-mediated airway inflammation
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