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Medchemexpress LLC ZL0580 | 2377151-10-3 | 99.4% | 532.53 | 10 MG
Supplier: Medchemexpress LLC HY12642810MG
ZL0580, an analog of ZL0590, epigenetically suppresses HIV by binding to the BD1 domain of BRD4. It inhibits Tat transactivation and transcription elongation, and also induces a repressive chromatin structure at the HIV promoter.
- Induces HIV transcriptional suppression.
- Exhibits low toxicity.
- Suppresses both PMA-stimulated and basal HIV transcription.
- Does not cause significant cell death at concentrations below 40 μM.
- Suppresses HIV in primary CD4+ T cells.
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