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Compounds (solids, liquids, gasses) with well-defined isotopic compositions that act as the ultimate sources of accuracy in mass spectrometric measurements of isotope ratios.
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Simazine is a triazine herbicide widely used in agriculture, potted plant, and tree production. It can induce apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice.
Triazine herbicide
Can inhibit maturation, disrupt spindle morphology, affect mitochondrial function, increase ROS levels, and induce DNA damage and early apoptosis of mouse oocytes
Can lead to immunosuppression and immunotoxicity in mice
Reduced proliferation of both spleen T and B cells in mice
Decreased the number of spleen CD4+ T lymphocytes, while CD8+ T cells remained unchanged in mice
Reduced immune function, higher intracellular [Ca2+], and oxidative stress in mice
Induced spleen immune cell apoptosis by reducing Bcl-2, while increasing Fas and Caspase-3 levels in mice
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Deruxtecan-d5 is a deuterium-labeled Deruxtecan. It is an ADC drug-linker conjugate made of an DX-8951 derivative and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.
Can be used as a tracer.
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development.
Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
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