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Standard-value, reference solutions designed for the exact calibration of spectrometers; standards guarantee that machines function properly for accurate spectral lines.
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Rimonabant hydrochloride (CAS 158681-13-1) is a small-molecule inverse agonist targeting the cannabinoid receptor subtype CB1 It is designed to modulate endocannabinoid signaling pathways thereby regulating processes related to appetite control lipid metabolism and energy homeostasis Rimonabant hydrochloride exerts its biological activity primarily through selective inverse agonism at CB1 receptors It demonstrates high receptor binding affinity with a Ki value of approximately 1 8 nM Based on these pharmacological properties Rimonabant hydrochloride holds research potential in cannabinoid receptor pharmacology metabolic regulation and obesity-associated disorders
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The 125 mL Zinc Standard is intended for QC Trace Metal Analysis. Use the standard with ICP-OES, ICP-MS and AA methods. This product is accredited to ISO Guide 34. The standard is provided in one 15 mL screw cap vial at 1,000 mg/L in HNO3and yields up to 2 liters after dilution. Store at room temperature.
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Annexin V is a calcium-dependent phospholipid-binding protein that specifically binds phosphatidylserine (PS) Normally PS is localized to the inner leaflet of the cell membrane lipid bilayer but during early stages of apoptosis PS flips from the inner leaflet to the outer surface of the plasma membrane where it is exposed to the extracellular environment Annexin V displays a high affinity for PS Fluorescein (FITC)-conjugated Annexin V can be used as a fluorescent probe in flow cytometry or fluorescent microscopy to detect apoptosis within 10-20 minutes The nuclear dye 7-Aminoactinomycin D (7-AAD) specifically binds to double-stranded DNA and fluoresces upon binding Under normal circumstances 7-AAD is cell-impermeable however in late apoptotic and dead cells 7-AAD can pass through cell membranes staining DNA Combining Annexin V-FITC with 7-AAD staining cells at different stages of apoptosis and dead cells can be distinguished effectively
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Annexin V is a Ca2 -dependent phospholipid-binding protein that specifically binds to phosphatidylserine (PS) Under normal conditions PS resides on the inner side of the cell membrane lipid bilayer However in early apoptosis PS translocates from the inner leaflet of the plasma membrane to the outer surface becoming exposed externally Annexin V exhibits high binding affinity for PS and when conjugated with fluorescent molecules (Cy5) it serves as a fluorescent probe to detect apoptosis using flow cytometry or fluorescence microscopy The staining procedure requires only 10 20 minutes PI specifically binds to double-stranded DNA to produce red fluorescence it is normally impermeant to intact cell membranes However during late-stage apoptosis or in dead cells PI penetrates the membrane to stain nuclear DNA Combined Annexin V-Cy5 and PI staining allows distinction between cells at various stages of apoptosis and dead cells
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More