AK-778-XXMU is a small-molecule antagonist of DNA binding inhibitor 2 (ID2) used for research applications. It binds ID2 with a reported KD of 129 nM, inhibits glioma cell migration and invasion, induces apoptosis, and modulates ID2-KDR signaling to affect VEGFA, MMP2/9, and PTEN.
- Potent ID2 binding (KD 129 nM).
- Demonstrated inhibition of glioma cell migration and invasion.
- Induces apoptosis in glioma cell lines.
- Modulates angiogenesis and invasion-related signaling pathways.
- High chemical purity (99.96%).
- Soluble in DMSO at 100 mg/mL; ultrasonic may be required.
- Stable as a powder at -20°C for long-term storage.