AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM, used for the study of glioma. It inhibits the ID2-KDR signaling axis, leading to the downregulation of downstream angiogenic factors and invasion-related proteins, and the upregulation of the tumor suppressor factor PTEN. This compound demonstrates significant cancer-suppressing potency by inhibiting cell migration and invasion of glioma cell lines and inducing apoptosis.
- Potent ID2 antagonist with a KD of 129 nM
- Inhibits cell migration and invasion of glioma cell lines
- Induces apoptosis
- Inhibits ID2-KDR signaling axis
- Downregulates angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9)
- Upregulates tumor suppressor factor (PTEN)