Organometallic Compounds
Apexbio Technology LLC PKI 14-22 amide, myristoylated 201422-03-9 1mg
PKI 14-22 amide myristoylated (CAS 201422-03-9) is a cell-permeable inhibitor of cAMP-dependent protein kinase (PKA) By competitively blocking PKA activity this peptide fragment interferes with the phosphorylation of serine/threonine residues on protein substrates thereby modulating downstream signaling pathways involved in gene expression apoptosis differentiation and cell proliferation In cellular models myristoylated PKI 14-22 amide inhibits PKA-mediated processes such as 8-bromo-cAMP-induced hyperalgesia and IgG-Fc receptor stimulated phagocytosis in neutrophils in a dose-dependent manner This compound serves as a valuable research tool for dissecting PKA function and exploring PKA-related pathophysiology including cancer and immune regulation
