Organometallic Compounds
Selleck Chemical LLC Bis-PEG3-acid S1350-100mg
Bis-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs
Medchemexpress LLC Bis-PEG5-acid 25g | 439114-13-3 | 338.35 | C14H26O9 | 25 G
Bis-PEG5-acid (4,7,10,13,16-pentaoxanonadecanedioic acid) is a polyethylene glycol (PEG)-based dicarboxylic acid linker used as a building block in PROTAC and medicinal chemistry. The hydrophilic PEG spacer provides aqueous solubility and flexibility for conjugation, and the two terminal carboxylic acid groups enable standard coupling reactions. Purity and lot-specific certificate of analysis are provided with each shipment.
- PEG-based dicarboxylic acid linker for PROTAC synthesis
- Two terminal carboxylic acid groups for amide or ester coupling
- Hydrophilic spacer increases solubility in aqueous media
- White to yellow solid, suitable for handling and storage
- Supplied in gram-scale quantities with batch certificate of analysis
Medchemexpress LLC Bis-PEG5-acid 100mg | 439114-13-3 | 100 MG
Bis-PEG5-acid is a polyethylene glycol (PEG) based bifunctional linker with two terminal carboxylic acids. It serves as a hydrophilic spacer for PROTAC synthesis and bioconjugation, enabling formation of amide or ester bonds while improving solubility and flexibility.
- Hydrophilic polyethylene glycol spacer.
- Two terminal carboxylic acids for coupling reactions.
- High purity suitable for research applications.
- Solid form, convenient for storage and handling.
- Available in laboratory pack sizes including 100 mg.
Medchemexpress LLC Bis-PEG5-acid 5g | 439114-13-3 | 338.35 g·mol⁻1 | C14H26O9 | 5 G
Bis-PEG5-acid is a polyethylene glycol (PEG)-based bifunctional linker with two terminal carboxylic acid groups, used as a hydrophilic spacer in PROTAC synthesis, bioconjugation, and medicinal chemistry to improve solubility and provide flexibility between binding motifs.
- Provides a flexible PEG5 spacer for conjugation and linker design.
- Two terminal carboxylic acid groups for straightforward coupling chemistry.
- High purity (99.9%) suitable for research applications.
- Available in laboratory pack sizes for small-scale synthesis.
- Enhances aqueous solubility of hydrophobic ligands and intermediates.
Medchemexpress LLC m-PEG3-CH2CH2COOH | 67319-28-2 | MFCD11041124 | 97.0% | 236.26 g·mol⁻¹ | C10H20O6 | 5 G
m-PEG3-CH2CH2COOH is a methoxy-terminated PEG3 carboxylic acid used as a short, flexible spacer for bioconjugation chemistry. It is employed as a non-cleavable linker in antibody-drug conjugate (ADC) assembly and as a PEG-based linker in PROTAC and other conjugation workflows, providing a terminal carboxylic acid for coupling reactions and improving solubility of conjugates.
- Methoxy-terminated PEG3 spacer providing flexibility.
- Terminal carboxylic acid suitable for amide coupling and esterification.
- Molecular weight 236.26 g·mol⁻¹ for predictable spacer length.
- High purity (approximately 97.0%) suitable for research applications.
- Available in small research-scale quantities and recommended refrigerated storage for stability.
Medchemexpress LLC 5,8,11-trioxa-2-azatetradecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester | 867062-95-1 | 99.8% | 443.49 g/mol | C24H29NO7 | 1 G
Fmoc-NH-PEG3-CH2CH2COOH is an Fmoc-protected PEG3 linker bearing a terminal carboxylic acid, used in research applications as a cleavable linker for antibody-drug conjugates and as a PEG-based linker for PROTAC synthesis.
- Fmoc-protected amine functionality for standard peptide chemistry
- Terminal carboxylic acid for conjugation
- High reported purity (≈99.8%)
- Molecular weight 443.49 g/mol
- Chemical formula C24H29NO7
- Available in small-scale quantities, including 1 G
Medchemexpress LLC Azido-PEG5-CH2CO2H | 217180-81-9 | 98.9% | 321.33 g/mol | C12H23N3O7 | 250 MG
Azido-PEG5-CH2CO2H is a cleavable, azide-functionalized polyethylene glycol (PEG) linker with a terminal carboxylic acid that provides a hydrophilic spacer and a reactive azide handle for bioconjugation and linker synthesis.
- Cleavable 5-unit PEG linker suitable for linker-based conjugation.
- Azide functional group for copper-catalyzed or strain-promoted click reactions.
- Terminal carboxylic acid enables further derivatization or coupling.
- Hydrophilic spacer increases solubility in aqueous media.
- High purity suitable for chemical synthesis and bioconjugation.
- Available in 250 MG pack size.
Medchemexpress LLC Fmoc-NH-PEG3-CH2CH2COOH | 867062-95-1 | 99.8% | 443.49 g/mol | C24H29NO7 | 5 G
Fmoc-NH-PEG3-CH2CH2COOH is an Fmoc-protected PEG3-based cleavable linker used for conjugation chemistry in research applications such as antibody-drug conjugates and PROTAC synthesis. It provides a short PEG spacer with an Fmoc-protected amino terminus and a terminal carboxylic acid for coupling reactions.
- High purity suitable for research use.
- PEG3 spacer provides solubility and flexibility.
- Fmoc protection enables standard amine deprotection workflows.
- Terminal carboxylic acid allows amide bond formation.
- Available in multiple pack sizes for synthesis scale-up.
Medchemexpress LLC Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH | 2351103-63-2 | 93.9% | 648.7 | C31H44N4O11 | 5 MG
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a pomalidomide-based cereblon ligand and a PEG-like linker; it is intended for use in PROTAC design, E3 ligase recruitment studies, and chemical probe synthesis.
- Incorporates a pomalidomide-based cereblon ligand for CRBN recruitment.
- Features a PEG-like C2 linker terminating in a carboxylic acid for conjugation.
- Supplied as a purified small-molecule reagent for probe and PROTAC synthesis.
- Available in multiple sizes to support screening and scale-up workflows.
- Analytical data for purity and molecular properties provided for reproducibility.
Medchemexpress LLC Acetoacetic acid (lithium) | 578486 | MFCD00013060 | 98.0% | 108.02 g/mol | C4H6LiO3 | 5 MG
Acetoacetic acid (lithium) is the lithium salt of acetoacetic acid supplied as a research reagent for biochemical and cell-based studies. It functions as an oxidative stress inducer and is provided as a small-quantity solid suitable for preparing aqueous or DMSO solutions for in vitro experiments.
- Oxidative stress inducer for cell and biochemical assays.
- High nominal purity (98.0%).
- Supplied as a 5 mg vial for small-scale research use.
- Soluble in water and DMSO for flexible formulation.
- Molecular weight 108.02 g/mol; formula C4H6LiO3.
- CAS number 3483-11-2 for unambiguous identification.
Medchemexpress LLC Folate-PEG3-C2-acid | 97.6% | 644.63 g/mol | C28H36N8O10 | 10 MG
Folate-PEG3-C2-acid is the acid fragment of a folate-PEG3-based NHS ester and serves as a PEG-type PROTAC linker building block used in the synthesis of PROTAC molecules and folate-conjugated ligands for receptor-targeting studies.
- Purity: 97.6%.
- Molecular weight: 644.63 g/mol.
- Solubility: soluble in DMSO at 33.33 mg/mL (51.70 mM); ultrasonication and heating may aid dissolution.
- Storage: store at 4°C protected from light; in solvent keep at -80°C (6 months) or -20°C (1 month), protected from light.
- Physical state: light yellow to yellow solid.
Medchemexpress LLC N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid | 2183440-74-4 | 98.1% | C29H55N5O13 | 10MG
N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a PEG-based linker designed for use in click chemistry and bioconjugation workflows. It features a terminal azide and orthogonally protected amine, providing versatility for PROTAC assembly and other synthetic applications.
- Terminal azide for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Compatible with strain-promoted alkyne-azide cycloaddition (SPAAC).
- PEG3 spacer provides flexibility and improved solubility.
- Boc-protected amine on PEG2 enables selective deprotection and further modification.
- Carboxylic acid terminus allows conjugation via standard amide coupling.
- High purity suitable for synthetic and bioconjugation workflows.
Medchemexpress LLC Tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate | 252881-73-5 | 303.3547 g/mol | C13H25N3O5 | 50 MG
N3-PEG3-CH2CH2-Boc is an azido-terminated PEG3 linker with a tert-butyl (Boc) protected carboxylic acid end, used as a cleavable PEG-based linker in antibody-drug conjugate and PROTAC synthesis, and as an azide reagent for click chemistry.
- Azide-terminated PEG3 linker suitable for click chemistry.
- tert-Butyl (Boc) protected carboxyl end for orthogonal deprotection.
- Used in ADC and PROTAC linker assembly.
- Available as a small pre-weighed laboratory pack for synthetic use.
Medchemexpress LLC Lipoamide-PEG3-mal | 1314378-19-2 | 99.6% | C25H41N3O7S2 | 10MG
Lipoamide-PEG3-Mal is a PEG-based linker that combines a lipoamide (lipoic acid derivative) moiety with a terminal maleimide. It is supplied for research use as a building block in the synthesis of PROTACs and other bioconjugates, providing flexible spacing and a thiol-reactive handle for selective conjugation.
- Peg3 spacer provides flexibility and improved solubility.
- Lipoamide moiety offers a bio-relevant functional group for linkage.
- Maleimide group enables rapid and selective thiol conjugation.
- High reported purity suitable for synthetic applications.
- Available in small, research-friendly package sizes.
Medchemexpress LLC Mal-PEG3-NH2 TFA | 2830214-77-0 | 99.1% | 386.32 g/mol | C14H21F3N2O7 | 50 MG
Mal-PEG3-NH2 TFA is a linear, heterobifunctional polyethylene glycol (PEG) crosslinker supplied as the trifluoroacetic acid (TFA) salt. It contains a maleimide at one end and a primary amine at the other, enabling thiol-to-amine conjugation and use as a non-cleavable linker in PROTAC and bioconjugation workflows. For research use only.
- Provides maleimide and primary amine reactive groups for orthogonal conjugation.
- PEG3 spacer improves aqueous solubility and reduces steric hindrance.
- TFA salt form enhances stability and handling compared with the free base.
- Non-cleavable linker suitable for stable conjugates and PROTAC constructs.
- High purity (>99%) for consistent conjugation performance.
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