Aminosaccharides
Sigma Aldrich Fine Chemicals Biosciences D-(+)-Galactosamine hydrochloride | 1772-03-8 | MFCD00135830 | 5 g
D-(+)-Galactosamine hydrochloride | Purity: ≥99% | Mol Wt: 215.63 | 1772-03-8 | MFCD00135830 | 5 g
Sigma Aldrich Fine Chemicals Biosciences D-(+)-Galactosamine hydrochloride >=99% | 1772-03-8 | MFCD00135830 | 25G
D-(+)-Galactosamine hydrochloride >=99% | Purity: >=99% | Mol Wt: 215.63 | 1772-03-8 | MFCD00135830 | 25G
Medchemexpress LLC D(+)-Galactosamine hydrochloride | 1772-03-8 | 99.9% | 215.63 | 25 MG
D(+)-Galactosamine hydrochloride is an established experimental toxin that primarily causes liver injury through the generation of free radicals and depletion of UTP nucleotides. Intoxication with D(+)-Galactosamine hydrochloride also induces renal dysfunction, with renal failure often associated with the end-stage of liver damage. The combination of Lipopolysaccharide/D(+)-Galactosamine is a known animal model for inducing acute liver injury, leading to fulminant hepatic failure.
- Causes liver injury through generation of free radicals.
- Leads to depletion of UTP nucleotides.
- Induces renal dysfunction.
- Useful in animal models for acute liver injury.
Sigma Aldrich Fine Chemicals Biosciences D-(+)-Galactosamine hydrochloride >=99% | 1772-03-8 | MFCD00135830 | 10MG
D-(+)-Galactosamine hydrochloride >=99% | Purity: >=99% | Mol Wt: 215.63 | 1772-03-8 | MFCD00135830 | 10MG
Medchemexpress LLC D(+)-Galactosamine hydrochloride | 1772-03-8 | 99.9% | 215.63 | 1 G
D(+)-Galactosamine hydrochloride is an established experimental toxin known to primarily cause liver injury by generating free radicals and depleting UTP nucleotides. It also induces renal dysfunction, often leading to renal failure associated with end-stage liver damage. This compound can be used to induce hepatitis models, mimicking viral hepatitis by causing lipid peroxidation and cell membrane deterioration.
- Induces apoptosis and necrosis in primary cultures of rat hepatocytes.
- Causes caspase-3 activation and DNA fragmentation.
- Used as an animal model for fulminant hepatic failure.
- Induces acute liver failure in mice when co-administered with Lipopolysaccharide.
Sigma Aldrich Fine Chemicals Biosciences 4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide suitable for fluorescence, >=99.0% (TLC) | 37067-30-4 | MFCD00150977 | 250MG
4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide suitable for fluorescence, >=99.0% (TLC) | Purity: >=99.0% (TLC) | Mol Wt: 379.36 | 37067-30-4 | MFCD00150977 | 250MG
Medchemexpress LLC Tak-418 hydrochloride | 1818252-53-7 | 99.8% | C17H25ClN2O2S | 10MG
TAK-418 is an orally active, CNS-penetrant inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) developed as a clinical candidate for neurodevelopmental and other central nervous system disorders. It is supplied as a research compound for in vitro and in vivo pharmacology, pharmacokinetics, and translational studies, with reported formula C17H25ClN2O2S and CAS 1818252-53-7.
- Selective LSD1 inhibition with reported low-nanomolar potency.
- Orally bioavailable and brain-penetrant for CNS studies.
- Suitable for in vitro and in vivo pharmacology.
- Available in small-mg research pack sizes for preclinical work.
- High reported purity for reproducible experimental results.
- Storage guidance supports long-term sample integrity.
Sigma Aldrich Fine Chemicals Biosciences 4-Methylumbelliferyl N-Acetyl-Beta-D-Glucosaminide | 37067-30-4 | MFCD00065481 | 1g
4-Methylumbelliferyl N-Acetyl-Beta-D-Glucosaminide | Mol Wt: 379.36 | 37067-30-4 | MFCD00065481 | 1g
Medchemexpress LLC Azidoethyl-SS-PEG2-Boc | 2144777-83-1 | 351.49 | 250 MG
Azidoethyl-SS-PEG2-Boc is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
- PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Apramycin (sulfate) | 65710-07-8 | MFCD06200257 | 98% | 1 G
Apramycin (EBL 1003) sulfate is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin sulfate is a potential anti-drug-resistance antibiotic.
- Orally active.
- Acidic pH tolerant.
- Aminoglycoside-modifying-enzymes-tolerant.
- Inhibits protein biosynthesis by targeting the bacterial ribosome.
- Potential anti-drug-resistance antibiotic.
- Store at 4°C, sealed, away from moisture.
- Store in solvent at -80°C for 6 months, or -20°C for 1 month.
Medchemexpress LLC D(+)-Galactosamine (hydrochloride) | 1772-03-8 | 99.9% | 215.63 | 200 MG
D(+)-Galactosamine hydrochloride is an established experimental toxin that primarily causes liver injury by generating free radicals and depleting UTP nucleotides. It also induces renal dysfunction, with renal failure often associated with the end-stage of liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure.
- Induces apoptosis and necrosis in primary cultures of rat hepatocytes.
- Induces caspase-3 activation and DNA fragmentation.
- Used to induce hepatitis models similar to viral hepatitis.
- Induces lipid peroxidation and deterioration of cell membranes.
- Can be used in rat models (Wistar) to study liver damage.
- Can be used in mouse models (C57BL/6J) for acute liver failure induction.
Chem-Impex International, Inc. N-Acetyl-D-galactosamine | 14215-68-0 | MFCD00065372 | 1G
N-Acetyl-D-galactosamine, 14215-68-0, MFCD00065372, 1G
Sigma Aldrich Fine Chemicals Biosciences Hyaluronic acid sodium salt from Streptococcus equi mol wt 2,000,000-2,400,000 | 9067-32-7 | MFCD01773053 | 50MG
Hyaluronic acid sodium salt from Streptococcus equi mol wt 2,000,000-2,400,000 | 9067-32-7 | MFCD01773053 | 50MG