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Carbohydrate derivatives in which a sugar is bound to another functional group via a glycosidic bond; play numerous roles in living organisms; may be classified and utilized based on glycone/presence of sugar, bond type, or agylcone.
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GA-017 inhibits the serine/threonine protein kinases large tumor suppressor kinase 1/2 (LATS1/2) which exerts inhibitory with IC50s against LATS1 and 2 of 4 10 0 79 and 3 92 0 42 nM respectively and competitively inhibits LATS1 and 2 against ATP with Ki (inhibition constant) values of 0 58 0 11 and 0 25 0 03 nM respectively
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