Steroids and derivatives
Medchemexpress LLC Estrone sulfate potassium | 1240-04-6 | 99.9% | 388.52 | 50 MG
Estrone sulfate potassium is an inactive endogenous estrogen, convertible to Estrone and Estradiol, and a substrate of the OATP1B3 transporter. It stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, making it applicable to breast cancer-related research.
- Inactive endogenous estrogen
- Can be converted into Estrone and Estradiol
- Substrate of the OATP1B3 transporter
- Stimulates growth of mammary tumors in ovariectomized rats
- Promotes colony formation of dispersed mammary cells
- Useful for breast cancer-related research
Medchemexpress LLC 5,6-trans-vitamin D2 | 51744-66-2 | 97.0% | C28H44O | 50 MG
5,6-trans-Vitamin D2 is an isomer of Vitamin D2. It is for research use only. This product is an off-white to light yellow solid.
- Isomer of Vitamin D2
- Off-white to light yellow solid
- For research use only
- Solubility in DMSO: 25 mg/mL (63.03 mM)
- Recommended storage for solid: -20°C, protect from light, stored under nitrogen
- Recommended storage in solvent: -80°C for 6 months, or -20°C for 1 month (protect from light, stored under nitrogen)
Medchemexpress LLC Bazedoxifene (acetate) | 198481-33-3 | 99.88% | C32H38N2O5 | 500 MG
Bazedoxifene acetate (TSE-424 acetate) is an oral, nonsteroidal selective estrogen receptor modulator (SERM). It has IC50s of 23 nM for ERα and 99 nM for ERβ. This compound is used in the research of osteoporosis. Additionally, Bazedoxifene acetate acts as an inhibitor of IL-6/GP130 protein-protein interactions and is utilized in research for pancreatic cancer.
- Oral, nonsteroidal selective estrogen receptor modulator (SERM)
- Exhibits IC50s of 23 nM for ERα and 99 nM for ERβ
- Used in osteoporosis and pancreatic cancer research
- Inhibits IL-6/GP130 protein-protein interactions and STAT3 phosphorylation
- Induces apoptosis and blocks cell migration in pancreatic cancer cells in vitro
- Inhibits Capan-1 tumor growth in a mouse model in vivo
Medchemexpress LLC Acetamide-2,2,2-d3, N-(4-hydroxyphenyl)- | 60902-28-5 | 100.0% | C8H6D3NO2 | 5 MG
Acetaminophen-d3 is the deuterium labeled form of Acetaminophen (Paracetamol), a widely used antipyretic and analgesic agent. It functions as a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM, and also acts as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. This isotope-labeled compound is for research use only.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Contains stable heavy isotopes for quantitation during drug development
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Estra-1,3,5(10)-triene-3,17-diol (17β)-, 17-(hydrogen butanedioate) | 7698-93-3 | 98.8% | 372.45 | 50 MG
β-Estradiol 17-hemisuccinate is a synthetic derivative of estradiol, appearing as a white to off-white solid.
- Synthetic derivative of estradiol.
- CAS number: 7698-93-3.
- Molecular weight: 372.45.
- Chemical formula: C22H28O5.
- Purity: 98.8%.
- Store at 4°C, stored under nitrogen.
- Store in solvent at -80°C for 6 months or -20°C for 1 month, stored under nitrogen.
- 1H NMR spectrum and LCMS consistent with structure.
Medchemexpress LLC Estra-1,3,5(10)-triene-3,17-diol (17β)-, 17-(hydrogen butanedioate) | 7698-93-3 | 98.8% | 372.45 | 100 MG
β-Estradiol 17-hemisuccinate is a synthetic derivative of estradiol. This compound is a white to off-white solid with a purity of 98.8%. It is suitable for research applications.
- Synthetic derivative of estradiol
- Purity of 98.8%
- Molecular weight of 372.45
- White to off-white solid appearance
- Store at 4°C under nitrogen
- Store in solvent at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO
Medchemexpress LLC Hexanoylglycine-d2 | 1256842-52-0 | 98.0% | 175.22 | 5 MG
Hexanoylglycine-d2 is the deuterium labeled Hexanoylglycine. Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules, primarily as tracers for quantitation during drug development. Deuteration is noted for its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled compound
- Used as tracers for quantitation in drug development
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Cayman Chemical DecnoIc AcId-d3 10mg
An internal standard for the quantification of decanoic acid by GC- or LC-MS
Medchemexpress LLC N-Butyrylglycine-d2 | 1219799-10-6 | 99.17% | 147.17 | 10 MG
N-Butyrylglycine-d2 is the deuterium labeled N-Butyrylglycine. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. This compound is for research use only.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC 17-hydroxy-11-dehydrocorticosterone | 53-06-5 | 99.3% | 360.44 | 5 G
Cortisone (17-Hydroxy-11-dehydrocorticosterone) is an oxidized metabolite of Cortisol, a Glucocorticoid. It functions as an immunosuppressant and anti-inflammatory agent. At high concentrations, Cortisone can partially interfere with the binding of Glucocorticoid to the Glucocorticoid-receptor. This product is intended for research use only.
- Oxidized metabolite of Cortisol
- Functions as an immunosuppressant
- Acts as an anti-inflammatory agent
- Partially interferes with Glucocorticoid-receptor binding
- For research use only
Enzo Life Sciences U-73343 (5 mg). CAS: 142878-12-4
Inactive analog of U-73122 (BML-ST391) which only slightly inhibits phospholipase C. May be used as a negative control. Alternative name: 1-[6-[[(17beta)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-pyrrolidine-2,5-dione. Purity: ≥98% (HPLC). Solubility: Soluble in methylene chloride or chloroform; slightly soluble in DMSO (2mg/ml) or 100% ethanol (1mg/ml); sparingly soluble in aqueous solutions. Long Term Storage: Ambient.
Medchemexpress LLC Hydrocortisone acepo 50mg | 74050-20-7 | 460.56 | C26H36O7 | 50 MG
Hydrocortisone aceponate (hydrocortisone 17-propionate 21-acetate) is a potent topical glucocorticoid supplied as a research-grade chemical standard for dermatological and pharmacological studies. The compound is supplied as a solid with high purity and is suitable for analytical and experimental applications.
- Potent topical glucocorticoid for dermatoses research.
- High purity (99.43%).
- Solid, white to off-white appearance.
- Molecular formula C26H36O7 and molecular weight 460.56.
- Available in multiple pack sizes, including 50 mg.
- Recommended storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (6 months) or -20°C (1 month).