Steroids and derivatives
Chem-Impex International, Inc. Dehydroepiandrosterone | MFCD00003613 | 25G
Dehydroepiandrosterone, MFCD00003613, 25G
Apexbio Technology LLC Estrone sulfate potassium 1240-04-6 10mg
Estrone sulfate potassium (1240-04-6) is a small-molecule modulator targeting kinase activities implicated in estrogen signaling pathways It is designed to regulate estrogen-mediated biological processes by modulating specific kinase activities thereby influencing cellular responses related to steroid signaling Estrone sulfate potassium exerts its biological activity primarily through modulation of kinase pathways associated with estrogen signaling Laboratory studies indicate that estrone sulfate potassium can influence cellular responses via targeted kinase inhibition pathways Based on these pharmacological properties estrone sulfate potassium holds research potential in elucidating pathological mechanisms and identifying therapeutic targets related to endocrine disorders
Apexbio Technology LLC Estrone 53-16-7 10mM (in 1mL DMSO)
Estrone (53-16-7) is a naturally occurring estrogen that modulates estrogen receptor-mediated signaling pathways It is primarily synthesized in ovarian and adipose tissues and participates in the regulation of estrogen-dependent cellular and physiological processes Estrone exerts its biological activity primarily through binding and activating estrogen receptors Experimental model activity type and key metric (IC50/EC50) are not specified Based on these pharmacological properties estrone holds research potential in studies of estrogen receptor activation reproductive endocrinology menopausal hormone transitions and estrogen-dependent signaling pathways and diseases
Innovative Reseach Of America INNOVATIVE RESEARCH OF AMERICA
NC3903870 0.36 MG 17B ESTRADIOL PELLETS
Selleck Chemical LLC Estradiol Cypionate S4046-1g
Estradiol cypionate is the 17 -cyclopentylpropinate ester of estradiol which inhibits ET-1 synthesis via estrogen receptor
Selleck Chemical LLC Alpha-Estradiol
Alpha-Estradiol ( -Estradiol 17 alpha-Estradiol Alfatradiol Epiestradiol Epiestrol Alora 17 -E2) a natural non-feminizing stereoisomer a hormonally almost inactive isomer of physiological 17 beta-estradiol (17 -E2) is a weak inhibitor of estrogen
Medchemexpress LLC Estradiol valerate | 979-32-8 | >99.9% | 25 MG
Estradiol valerate is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents. It is for research use only and not sold to patients. It is also identified as a reproductive toxicant and estrogenic chemical in both male and female fish.
- Molecular weight: 356.50
- Formula: C23H32O3
- Appearance: Solid, white to off-white
- Shipping: Room temperature in continental US
- Storage: Powder at -20°C for 3 years, 4°C for 2 years; in solvent at -80°C for 2 years, -20°C for 1 year
- Solubility in DMSO: ≥ 50 mg/mL (140.25 mM)
- Solubility in ethanol: 12.5 mg/mL (35.06 mM)
- Insoluble in H2O
- Target: Estrogen Receptor/ERR
Medchemexpress LLC Estradiol enanthate | 4956-37-0 | 98.1% | 1 ML
Estradiol enanthate (E2EN) is a shorter-acting estrogen. It is an injectable contraceptive when combined with Dihydroxyprogesterone acetophenide. Estradiol enanthate promotes withdrawal bleeding, similar to menstruation. It is for research use only and not sold to patients.
- Molecular weight: 384.55
- Formula: C25H36O3
- Appearance: Solid
- Color: White to off-white
- SMILES: C[C@@]12[C@@H](OC(CCCCCC)=O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC2
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: 4°C, sealed storage, away from moisture and light; In solvent: -80°C for 6 months, -20°C for 1 month (sealed storage, away from moisture and light)
- Solubility (In Vitro): DMSO: 125 mg/mL (325.06 mM; requires ultrasonic; hygroscopic DMSO impacts solubility, use newly opened DMSO); Ethanol: ≥ 100 mg/mL (260.04 mM)
Medchemexpress LLC Estradiol enanthate (E2EN) | 4956-37-0 | 98.1% | 500 MG
Estradiol enanthate (E2EN) is a shorter-acting estrogen. It is an injectable contraceptive when combined with Dihydroxyprogesterone acetophenide. It promotes withdrawal bleeding similar to menstruation and is intended for research use only.
- Molecular weight: 384.55
- Formula: C25H36O3
- Appearance: Solid
- Color: White to off-white
- Solubility in DMSO: 125 mg/mL (325.06 mM; requires ultrasonic)
- Solubility in ethanol: ≥ 100 mg/mL (260.04 mM)
- Shipping: Room temperature in continental US
- Storage: 4°C, sealed storage, away from moisture and light. In solvent: -80°C for 6 months; -20°C for 1 month (sealed storage, away from moisture and light).
Medchemexpress LLC Estradiol cypionate | 313-06-4 | MFCD00056558 | 99.5% | 1 ML
Estradiol cypionate is the 17β-cypionate ester of Estradiol, inhibiting ET-1 synthesis by acting on estrogen receptors. It is intended for research use only. In vitro, it inhibits proliferation of gastric cancer cells and induces G1/S phase cell cycle arrest and apoptosis by affecting the PI3K/Akt/mTOR pathway. In vivo, it increases cortical bone density in ovariectomized rabbits, increases occurrence of estrus and pregnancy in cows, and inhibits tumor growth in MGC803 nude mice tumor models.
- Inhibits gastric cancer cell proliferation
- Induces G1/S phase cell cycle arrest and apoptosis
- Increases cortical bone density
- Promotes estrus and pregnancy
- Inhibits tumor growth
Medchemexpress LLC Estradiol 3-glucuronide sodium | 14982-12-8 | 1 MG
Estradiol 3-glucuronide sodium is an estrogen metabolite, a glucuronide conjugate formed in tissues like the liver from Estradiol. It is a potent substrate of Mrp2, achieving hepatobiliary transport in hepatocytes via basolateral uptake through OATP1B1, OATP1B3, and OATP2B1, and apical efflux via MRP2 and BCRP. For research use only.
- Substrate for OATP1B1, OATP1B3, and OATP2B1 in HEK293T cells.
- Uptake inhibited by OATP substrates and inhibitors.
- Inhibits OATP1B3- and OATP2B1-mediated estrone-3-sulfate uptake.
- Inhibits OATP1B1-, OATP1B3-, OATP2B1-mediated Rosuvastatin uptake.
- Substrate of rat Mrp2 in Sf9 cell membrane vesicles.
- Competitively inhibits rat Mrp2-mediated Estradiol 17-glucuronide transport.
- Used to produce high-affinity antiserum for radioimmunoassay in urine samples.