Steroids and derivatives
Cayman Chemical Estradiol Benzoate
An estradiol analog; often used in combination with a progestin to induce estrus in domestic livestock; binds to human, murine, and chicken ERα IC50s = 22-28 nM)
Medchemexpress LLC Cortisone acetate | 50-04-4 | 98.9% | 402.48 | 10MM/1ML
Cortisone acetate (Cortisone 21-acetate) is an oxidized metabolite of Cortisol (a Glucocorticoid). It acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in the binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
- Acts as an immunosuppressant
- Acts as an anti-inflammatory agent
- Can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations
Apexbio Technology LLC Estradiol Benzoate 50-50-0 1g
Estradiol benzoate (50-50-0) is a small-molecule agonist targeting estrogen receptors exhibiting high binding affinity for estrogen receptor alpha (ER ) It is designed to activate ER thereby modulating estrogen-mediated signaling pathways and hormonal regulation processes Estradiol benzoate exerts its biological activity primarily through ER agonism In in vitro assays involving human murine and chicken ER proteins estradiol benzoate demonstrates agonistic activity with an IC50 value ranging between 22 28 nM Based on these pharmacological properties estradiol benzoate holds research potential in studies of ER-mediated signaling endocrine-related diseases receptor-ligand binding analyses pharmacological screening and investigations of estrogen-dependent physiological and pathological conditions
Apexbio Technology LLC Dexamethasone phosphate disodium 2392-39-4 500mg
Dexamethasone phosphate disodium (CAS 2392-39-4) is a small-molecule agonist targeting the glucocorticoid receptor It is designed to modulate glucocorticoid-mediated signaling pathways thereby regulating immune and inflammatory responses Dexamethasone phosphate disodium exerts its biological activity primarily by binding to the glucocorticoid receptor initiating nuclear translocation and influencing gene transcription to suppress the expression and secretion of pro-inflammatory cytokines and chemokines Based on these pharmacological properties dexamethasone phosphate disodium holds research potential in studying inflammatory conditions immune response processes and associated signaling cascades in vitro and in vivo
Cambridge Isotope Laboratories Melatonin (acetyl-D3 98%) CP 95% 10 mg
Melatonin (acetyl-D3 98%) CP 95% 10 mg
Medchemexpress LLC Cyclin D3/CCND3 Antibody (YA484) | 33 kDa | 100 UL
Cyclin D3/CCND3 Antibody (YA484) is a Rabbit-derived, non-conjugated IgG monoclonal antibody targeting Cyclin D3/CCND3. This protein is a regulatory component of the cyclin D3-CDK4 complex, crucial for regulating the cell cycle during G(1)/S transition by phosphorylating retinoblastoma (RB) protein family members.
- Host: Rabbit
- Reactivity: Human, Mouse
- Clonality: Monoclonal
- Target: Cyclin D3/CCND3
- Applications: WB, ICC/IF
- Storage: Store at -20°C for 1 year. Avoid repeated freeze/thaw cycles.
- Formulation: Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
- Purity: Protein A affinity purified.
Medchemexpress LLC Cagrilintide acetate | 1415456-99-3 | CB712152538 | 99.96% | 4409.01 | 5 MG
Cagrilintide acetate is a non-selective AMYR/CTR agonist and a long-acting acylated amylase analogue. It reduces food intake and causes significant weight loss in a dose-dependent manner, making it suitable for obesity studies.
- Non-selective AMYR/CTR agonist
- Long-acting acylated amylase analogue
- Reduces food intake
- Causes significant weight loss in a dose-dependent manner
- Suitable for obesity studies
- For research use only
Cambridge Isotope Laboratories 24R 25-Dihydroxyvitamin D3 (unlabeled) 100 ug/mL in ethanol CP 97% 1 mL
24R 25-Dihydroxyvitamin D3 (unlabeled) 100 ug/mL in ethanol CP 97% 1 mL
Cayman Chemical Resolvin D2 Neurochemicals
A product of the action of 15- and 5-LO on DHA; dampens excessive neutrophil trafficking to sites of inflammation; reduces zymosan-stimulated PMN infiltration by 70% at 10 pg per mouse; reduces PAF-stimulated leukocyte adherence and emigration at 1 nM; stimulates nitric oxide production decreases leukocyte-endothelial interactions; reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance in a mouse model of sepsis
Medchemexpress LLC Dopamine Receptor D3 Antibody (YA1742) | 10 UL
Dopamine Receptor D3 Antibody (YA1742) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting Dopamine Receptor D3. Its function is mediated by G proteins which inhibit adenylyl cyclase and it promotes cell proliferation. It is supplied in 10mM phosphate buffered saline, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
- Host: Rabbit
- Clonality: Recombinant, Monoclonal
- Species reactivity: Human, Mouse, Rat
- Immunogen: A synthesized peptide derived from human Dopamine Receptor D3 aa1-50/400
- Application: WB (Western Blot) at 1:500-1:1000 dilution
- Sensitivity: Endogenous
- Conjugation: Non-conjugated
- Modification: Unmodified
- Isotype: IgG
- Appearance: Liquid
- Subcellular localization: Cell membrane; Multi-pass membrane protein
- Expression tissue specificity: Brain
Apexbio Technology LLC TRO 19622 22033-87-0 5mg
TRO 19622 (CAS 22033-87-0) also known as Olesoxime is a cholesterol-like small molecule that modulates mitochondrial function contributing to cellular resilience under stress conditions Preclinical studies demonstrate that TRO 19622 attenuates neurodegeneration supports nerve function and facilitates neuroregeneration following traumatic nerve injury in both in vitro and in vivo models This compound is utilized in research exploring neuroprotection and mechanisms underlying neuronal survival with potential applications in models of neurodegenerative diseases and peripheral nerve trauma
Cambridge Isotope Laboratories 6-Methoxy-2 2 4 4 5-pentaBDE (unlabeled) 50 ug/mL in nonane 1 2 mL
6-Methoxy-2 2 4 4 5-pentaBDE (unlabeled) 50 ug/mL in nonane 1 2 mL
Apexbio Technology LLC α-Estradiol 57-91-0 10mM (in 1mL Ethanol)
alpha-Estradiol (57-91-0) is a small-molecule inhibitor targeting 5 -reductase the enzyme responsible for converting testosterone to dihydrotestosterone (DHT) It is designed to inhibit 5 -reductase activity thereby modulating androgen metabolism and androgen-related signaling pathways alpha-Estradiol exerts its biological activity primarily through enzyme inhibition In reported experimental studies alpha-Estradiol demonstrates inhibitory activity against 5 -reductase with an IC50 value ranging from approximately 1 to 10 M though the precise value may depend on assay conditions Based on these pharmacological properties alpha-Estradiol holds research potential in the treatment and study of androgenetic alopecia
Cayman Chemical Resolvin D2 Neurochemicals
A product of the action of 15- and 5-LO on DHA; dampens excessive neutrophil trafficking to sites of inflammation; reduces zymosan-stimulated PMN infiltration by 70% at 10 pg per mouse; reduces PAF-stimulated leukocyte adherence and emigration at 1 nM; stimulates nitric oxide production decreases leukocyte-endothelial interactions; reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance in a mouse model of sepsis