Purine nucleotides
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Medchemexpress LLC Adenosine amine congener (ADAC) | 96760-69-9 | 99.2% | 1 ML
Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist known for its ability to ameliorate noise- and cisplatin-induced cochlear injury. It also exhibits neuroprotective effects by reducing oxidative stress and inhibiting apoptosis in cochlear tissues, thereby protecting sensory hair cells and strial marginal cells.
- Selective A1 adenosine receptor agonist
- Ameliorates noise-induced cochlear injury
- Reduces cisplatin-induced cochlear injury
- Provides neuroprotective effects
- Reduces oxidative stress in noise-exposed cochlea
- Inhibits glutamate release via presynaptic A1 receptors
- Inhibits voltage-gated Ca2+ channels
- Prevents activation of apoptotic and necrotic cell death pathways
- Mitigates noise-induced hearing loss in a dose- and time-dependent manner
