Drug Standards
Selleck Chemical LLC Conivaptan HCl 10mg 168626-94-6
Conivaptan HCl is an orally active, non-peptide, vasopressin V1A and V2 receptor antagonist, used in the treatment of euvolemic and hypervolemic hyponatremia. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Deshydroxyethoxy-2,3-O-(dimethylmethylene) ticagrelor | 274693-49-1 | 10 MG
Ticagrelor impurity 22 is an analytical reference standard used as a drug impurity reference for analytical and research applications. It is characterized by CAS 274693-49-1 and molecular formula C24H28F2N6O3S, with a molecular weight of 518.58 g/mol. The manufacturer provides a datasheet and certificate of analysis with recommended storage and handling instructions.
- Intended for analytical and research use only.
- Provides a defined reference for impurity profiling and method validation.
- Characterized by CAS 274693-49-1 and molecular formula C24H28F2N6O3S.
- Supplied in small laboratory quantities for analytical workflows.
- Store per certificate of analysis; check CoA for exact conditions.
Sigma Aldrich Fine Chemicals Biosciences Prilocaine Related Compound B United States Pharmacopeia (USP) Reference Standard | 744961-76-0 | 50MG
Prilocaine Related Compound B United States Pharmacopeia (USP) Reference Standard | Mol Wt: 220.31 | 744961-76-0 | 50MG
Selleck Chemical LLC Sonidegib (NVP-LDE225) 25mg 956697-53-3 Erismodegib
Sonidegib (Erismodegib, NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Nitisinone 104206-65-7 10mM (in 1mL DMSO)
Nitisinone (CAS 104206-65-7) is a synthetic small molecule that selectively inhibits 4-hydroxyphenylpyruvate dioxygenase an enzyme involved in the catabolic pathway of tyrosine By blocking this enzyme nitisinone disrupts the conversion of 4-hydroxyphenylpyruvate to homogentisic acid leading to reduced production of toxic tyrosine metabolites This mechanism is utilized in studies of hereditary tyrosinemia type 1 where nitisinone serves as a pharmacological tool to investigate metabolic regulation and therapeutic intervention in tyrosine degradation disorders
Sigma Aldrich Fine Chemicals Biosciences Phosphatidylinositol (Soy) Sodium United States Pharmacopeia (USP) Reference Standard | 383907-36-6 | 20mg
Phosphatidylinositol (Soy) Sodium United States Pharmacopeia (USP) Reference StandardPurity: MW: | 383907-36-6 | 20mg
Apexbio Technology LLC R788 disodium 1025687-58-4 5mg
R788 disodium (CAS 1025687-58-4) is a prodrug of the active metabolite R406 a selective inhibitor of spleen tyrosine kinase (Syk) Syk mediates signaling downstream of activated Fc and B-cell receptors (BCR) In vitro R406 suppresses constitutive and ligand-stimulated BCR signaling in diffuse large B-cell lymphoma (DLBCL) lines by inhibiting Syk autophosphorylation (SYK525/526) and associated phosphorylation of BLNK inducing apoptosis In vivo R788 reduces malignant B-cell proliferation and tumor progression in E -TCL1 mice Clinically R788 has shown utility in rheumatoid arthritis improving therapeutic response rates in phase II trials
Apexbio Technology LLC Flavopiridol hydrochloride 131740-09-5 1g
Flavopiridol hydrochloride is a selective inhibitor of cyclin-dependent kinases (CDKs) specifically targeting CDK1 CDK2 CDK4 and CDK6 with reported IC50 values approximately 41 nM and CDK7 with an IC50 of about 300 nM Additionally it has been observed to inhibit EGFR and protein kinase A at micromolar concentrations By inhibiting CDK activity flavopiridol hydrochloride disrupts cell cycle progression inducing G1 phase arrest as demonstrated in breast cancer cell lines Furthermore its capacity to inhibit phosphorylation of Rb protein and suppress anti-apoptotic proteins such as Mcl-1 and XIAP facilitates apoptosis in lymphoma cell models Flavopiridol hydrochloride is utilized in preclinical studies of cell cycle regulation apoptosis signaling and cancer research including experiments using xenograft tumor models in mice
Apexbio Technology LLC Eltrombopag Olamine 496775-62-3 50mg
Eltrombopag Olamine is an orally bioavailable thrombopoietin receptor (c-mpl) agonist that directly stimulates platelet production through activation of the JAK2/STAT signaling pathway In cellular assays using murine BAF3 cells expressing human thrombopoietin receptor (hTpoR) eltrombopag induced STAT-dependent signaling responses with an EC50 value of approximately 0 27 M This compound promotes differentiation of human CD34 progenitor cells into megakaryocytes capable of platelet production Eltrombopag is commonly applied in hematological research particularly in studies involving thrombocytopenia and thrombopoiesis-related mechanisms
Cayman Chemical TemozolomIde-d3 500ug
An internal standard for the quantification of temozolomide by GC- or LC-MS
Sigma Aldrich Fine Chemicals Biosciences Poly(vinyl acetate) dispersion 30 per cent European Pharmacopoeia (EP) Reference Standard | 9003-20-7 |
Poly(vinyl acetate) dispersion 30 per cent European Pharmacopoeia (EP) Reference Standard | 9003-20-7 |
Apexbio Technology LLC MEK162 (ARRY-162, ARRY-438162) 606143-89-9 10mg
MEK162 (ARRY-162 ARRY-438162 CAS 606143-89-9) is a selective inhibitor of MEK1 and MEK2 kinases exhibiting an IC50 of approximately 12 nM By targeting the MAPK/ERK signaling pathway MEK162 inhibits ERK1/2 phosphorylation reduces clonal survival and induces apoptosis in melanoma cell models including those harboring N-RAS GNAQ or GNA11 mutations Studies also indicate that combining MEK162 with PKC inhibitors leads to sustained suppression of MAPK signaling and enhanced pro-apoptotic effects in uveal melanoma cells Early-phase clinical research has reported transient typically mild retinopathy associated with MEK162 treatment This compound is widely utilized in studies of targeted melanoma therapies
Medchemexpress LLC Dacomitinib impurity 9 | 2117703-26-9 | 10mg
Dacomitinib impurity 9 is an impurity of Dacomitinib (HY-13272)
U.S. Pharmacopeia Ketorolac Related Compound A, 167105-80-8, MFCD27978189, 20 mg
Empirical Formula (Hill Notation): C19H22N2O5, Molecular Weight: 358.39, Synonym: 5-Benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide.
U.S. Pharmacopeia Ketorolac Related Compound B, 154476-25-2, MFCD28411605, 20 mg
Empirical Formula (Hill Notation): C14H13NO2, Molecular Weight: 227.26, Synonym: 5-Benzoyl-2,3-dihydro-1H-pyrrolizin-1-ol.