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Filtered Search Results
Medchemexpress LLC Cjoc42 | 2171519-89-2 | 99.0% | 415.46 | 100 MG
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Cjoc42 is a compound capable of binding to gankyrin, an oncoprotein that plays a critical role in cancer development. It inhibits gankyrin activity in a dose-dependent manner, thereby preventing the decrease in p53 protein levels that is often associated with high amounts of gankyrin. This action helps to restore p53-dependent transcription and enhance sensitivity to DNA damage, offering potential as an anti-cancer agent. It targets MDM-2/p53 pathway, associated with apoptosis.
- Binds to gankyrin and inhibits its activity
- Restores p53-dependent transcription
- Enhances sensitivity to DNA damage
- Recommended storage at 4°C, protected from light
- Soluble in DMSO
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eMolecules Diethyl Malonate | Oakwood Chemical | 105-53-3 | MFCD00009195 | 160.169 | C7H12O4 | 99.000 | CCOC(=O)CC(=O)OCC | 25g | 537703836
Diethyl Malonate | Oakwood Chemical | 105-53-3 | MFCD00009195 | 160.169 | C7H12O4 | 99.000 | CCOC(=O)CC(=O)OCC | 25g | 537703836
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Medchemexpress LLC Sennoside C | 37271-16-2 | 848.76 | 1 MG
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Sennoside C is an orally active component of the traditional Chinese medicine Sennae Folium. It can bind to human lysozyme and inhibit its amyloid fibrosis (IC50: 186.20 μM). It also possesses purgative activity and is used in the research of diarrhea and anti-amyloid related diseases.
- Solid appearance
- Color is white to yellow
- Structure classification: Quinones, anthraquinones, phenols, polyphenols
- Initial source: Plants, leguminosae, cassia angustifolia
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eMolecules Medchem Express / Dextrorotation nimorazole phosphate ester / 5mg / 446269365 / HY-18716 / / 1124347-33-6 / MFCD29472251 / 350.268 / C11H19N4O7P
Medchem Express / Dextrorotation nimorazole phosphate ester / 5mg / 446269365 / HY-18716 / / 1124347-33-6 / MFCD29472251 / 350.268 / C11H19N4O7P
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eMolecules Ambeed / 1-(2-Bromo-4-methylthiazol-5-yl)ethanone / 100mg / 490569247 / A877150 / / 1093106-54-7 / MFCD19370713 / 220.080 / C6H6BrNOS
Ambeed / 1-(2-Bromo-4-methylthiazol-5-yl)ethanone / 100mg / 490569247 / A877150 / / 1093106-54-7 / MFCD19370713 / 220.080 / C6H6BrNOS
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eMolecules Pharmablock / 5-ethoxypyridine-2-carboxylic acid / 25mg / 665626984 / PBT2928 / 0.000 / 98353-08-3 / MFCD13562922 / 167.164 / C8H9NO3
Pharmablock / 5-ethoxypyridine-2-carboxylic acid / 25mg / 665626984 / PBT2928 / 0.000 / 98353-08-3 / MFCD13562922 / 167.164 / C8H9NO3
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eMolecules Medchem Express / PDE10-IN-5 / 5mg / 719836101 / HY-14550A / / 898562-99-7 / [null] / 460.460 / C26H19F3N4O
Medchem Express / PDE10-IN-5 / 5mg / 719836101 / HY-14550A / / 898562-99-7 / [null] / 460.460 / C26H19F3N4O
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Medchemexpress LLC C12H12N4O2S2 | 675104-49-1 | 99.8% | 308.38 | 100 MG
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DSHS00884 is a potent human papillomavirus E6 inhibitor with an IC50 of 10 μM. It stabilizes p53 levels in HPV-positive cells by blocking E6-mediated p53 degradation with an IC50 of 2.5-25 μM.
- Potent human papillomavirus E6 inhibitor
- Ic50 of 10 μM against human papillomavirus E6
- Stabilizes p53 levels in HPV-positive cells
- Blocks E6-mediated p53 degradation
- Ic50 of 2.5-25 μM for blocking E6-mediated p53 degradation
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Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 100 MG
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SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. It inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis. This compound is used for type 2 diabetes research.
- Inhibits human TXNIP promoter activity in INS-1 cells
- Reduces TXNIP mRNA and protein levels in INS-1 cells
- Inhibits Pol II binding to the E-box motif of the TXNIP promoter
- Lowers glucagon secretion in TC1-6 cells
- Inhibits glucagon-induced glucose output from primary hepatocytes
- Decreases glucagon secretion and blocks hepatic glucose output in mice
- Well tolerated in C57BL/6J mice
- Reverses obesity- and streptozotocin-induced diabetes and hepatic steatosis in mice
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Sigma Aldrich Fine Chemicals Biosciences Hypericum perforatum extract secondary reference standard | 84082-80-4 | 500MG
Hypericum perforatum extract secondary reference standard | 84082-80-4 | 500MG
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Medchemexpress LLC Diazinon | 333-41-5 | 99.3% | 100 MG
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Diazinon is an orally active, irreversible AChE inhibitor and insecticide that can be absorbed through the digestive system, skin, or respiratory tract. It inhibits AChE, leading to the accumulation of acetylcholine, which overstimulates ACh receptors and affects the nervous system. Diazinon also produces reactive oxygen species (ROS), inducing oxidative stress in various tissues. It is mainly used in agriculture as an insecticide and may affect human and animal health.
- Inhibits cell viability in BRL-3A cells and spleen mononuclear cells.
- Increases ROS generation and lipid peroxidation in BRL-3A cells.
- Induces cell cycle arrest at the G1 phase of SMC cells.
- Affects swimming behavior in Daphnia pulex.
- Causes a decrease in renal reduced glutathione in rats.
- Induces histopathological changes in the thymus and spleen of mice.
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eMolecules AstaTech / 2-CHLORO-6-(TRIFLUOROMETHOXY)ISONICOTINIC ACID / 0.1g / 722706844 / FD10674 / 95.000 / 1221171-97-6 / MFCD22571780 / 241.550 / C7H3ClF3NO3
AstaTech / 2-CHLORO-6-(TRIFLUOROMETHOXY)ISONICOTINIC ACID / 0.1g / 722706844 / FD10674 / 95.000 / 1221171-97-6 / MFCD22571780 / 241.550 / C7H3ClF3NO3
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eMolecules Ambeed / 2-Methyl-12-di(pyridin-3-yl)propan-1-one / 1mg / 761012613 / A341725 / / 54-36-4 / MFCD00006397 / 226.279 / C14H14N2O
Ambeed / 2-Methyl-12-di(pyridin-3-yl)propan-1-one / 1mg / 761012613 / A341725 / / 54-36-4 / MFCD00006397 / 226.279 / C14H14N2O
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AdipoGen Geraniol
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Chemical. CAS 106-24-1. Formula C10H18O. MW 154.3. Geraniol is a terpene alcohol with a pleasant rose-like aroma, known as an important ingredient in many essential oils, and is used commercially as a fragrance compound in cosmetic and household products. Geraniol has diverse biological activities, including insecticide, antioxidant, anti-inflammatory, anticancer, antimicrobial properties, and hepatoprotective, cardioprotective and neuroprotective effects. Geraniol induces apoptosis in various cancer cells. Formulations containing geraniol have been used as fragrance ingredients and as insecticides in agriculture. Geraniol is produced by the scent glands of honeybees to mark nectar-bearing flowers and locate the entrances to their hives. It is also commonly used as an insect repellent, especially for mosquitoes. This compound can be used as analytical reference material.
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Bioworld 5-FOA, Monohydrate, 250 mg
Used as a research tool in molecular genetics. Employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5-phosphate decarboxylase deficient. 5-FOA is converted 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potential inhibitor of thyidylate Sythase (TS), causing a cessation in DNA synthesis.Specification:Synonyms: 5-FOA; FOA, 2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic Acid; 5-Fluorouracil-4-carboxylic AcidHarmful by inhalation, in contact with skin and if swallowed.References: Kondo, S. et al., (1991) J. Bacteriology, 173 (23), 7698-7700.Vidal, M. et al., (1996) Proc. Natl. Acad. Sci. USA, 93, 10321.ml> false false false ml> ml> false false false ml> Appearance: SolidMelting Point: ~285° C
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