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Filtered Search Results
eMolecules Ambeed / 3-Methyl-5-nitrobenzoic acid / 1g / 552651206 / A213161 / / 113882-33-0 / MFCD00129754 / 181.147 / C8H7NO4
Ambeed / 3-Methyl-5-nitrobenzoic acid / 1g / 552651206 / A213161 / / 113882-33-0 / MFCD00129754 / 181.147 / C8H7NO4
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![eMolecules Ambeed / 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide / 5g / 600827878 / A1149775 / / 404001-48-5 / [null] / 531.570 / C18H31F6N3O4S2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
eMolecules Ambeed / 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide / 5g / 600827878 / A1149775 / / 404001-48-5 / [null] / 531.570 / C18H31F6N3O4S2
Ambeed / 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide / 5g / 600827878 / A1149775 / / 404001-48-5 / [null] / 531.570 / C18H31F6N3O4S2
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eMolecules Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate | 2082-79-3 | MFCD00017498 | 25g
Ambeed | Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate | 25g | 525080237 | A164280 | | 2082-79-3 | MFCD00017498 | 530.878 | C35H62O3
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eMolecules AstaTech / 2-(4-METHOXYPHENYL)-2-THIOMORPHOLINOACETIC ACID HCL / 0.25g / 112532195 / AR3281 / 95.000 / 1214094-90-2 / MFCD11040526 / 303.800 / C13H18ClNO3S
AstaTech / 2-(4-METHOXYPHENYL)-2-THIOMORPHOLINOACETIC ACID HCL / 0.25g / 112532195 / AR3281 / 95.000 / 1214094-90-2 / MFCD11040526 / 303.800 / C13H18ClNO3S
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Medchemexpress LLC CE-245677 10mg | 717899-97-3 | 98.14% | 513.38 | 10 MG
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CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with cellular IC50s of 4.7 and 1 nM.
- Potent reversible inhibitor of Tie2 and TrkA/B kinases.
- Exhibits cellular IC50s of 4.7 nM for Tie2 and 1 nM for TrkA/B.
- Shows >100x selectivity against various other angiogenic receptor tyrosine kinases, including KDR, PDGFR, and FGFR.
- Demonstrates good oral absorption in in vivo rat PK studies with an oral bioavailability (F) of 80%.
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eMolecules Pharmablock / 3-(benzyloxy)azetidine hydrochloride / 25mg / 721310750 / PBLG1211-1 / 0.000 / 897019-59-9 / MFCD09907646 / 199.680 / C10H14ClNO
Pharmablock / 3-(benzyloxy)azetidine hydrochloride / 25mg / 721310750 / PBLG1211-1 / 0.000 / 897019-59-9 / MFCD09907646 / 199.680 / C10H14ClNO
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eMolecules Pharmablock / 5-chloro-3-nitro-pyridine-2-carboxylic acid / 25mg / 788494950 / PBCH425 / 0.000 / 899423-94-0 / MFCD08061312 / 202.550 / C6H3ClN2O4
Pharmablock / 5-chloro-3-nitro-pyridine-2-carboxylic acid / 25mg / 788494950 / PBCH425 / 0.000 / 899423-94-0 / MFCD08061312 / 202.550 / C6H3ClN2O4
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Medchemexpress LLC Acetamide, N-ethyl-2-[(6-methoxy-3-pyridinyl) [(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)- | 680590-49-2 | 99.9% | 454.54 | 100 MG
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EMPA is a high-affinity, reversible and selective orexin OX2 receptor antagonist. It binds to human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively. EMPA competitively antagonizes orexin-A-and orexin-B-evoked accumulation of [3H]inositol phosphates (IP) at hOX2 receptors. It displaces [3H]EMPA binding from cell membranes containing human and rat OX2 receptors.
- High-affinity, reversible and selective orexin OX2 receptor antagonist
- Binds to human and rat OX2-HEK293 membranes
- Inhibits orexin-A-or orexin-B-evoked [Ca2+]i response
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Medchemexpress LLC SMIFH2 | 340316-62-3 | 99.1% | 377.21 | 50 MG
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SMIFH2 is a formin specific inhibitor that inhibits actin polymerization by Formins and affects the actin cytoskeleton. It induces dynamic cytoskeletal remodelling in U2OS cells at 25 uM. SMIFH2 also reduces p300, mDia2 and p53 levels in a proteasome-independent manner and reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism that influences remodelling of the cytoskeleton.
- Formin specific inhibitor
- Inhibits actin polymerization by Formins
- Affects the actin cytoskeleton
- Induces dynamic cytoskeletal remodelling in U2OS cells
- Reduces p300, mDia2 and p53 levels in a proteasome-independent manner
- Reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism
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Medchemexpress LLC WNK-IN-11-d3 | 2123483-49-6 | 99.8% | 465.41 | 10 MG
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WNK-IN-11-d3 is an orally active, selective, and potent With-No-Lysine (WNK) kinase inhibitor. It is effective at regulating cardiovascular homeostasis. This compound can be used as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Orally active, selective, and potent WNK kinase inhibitor
- Regulates cardiovascular homeostasis
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
- Improves rat PK profile, including lower clearance and enhanced oral bioavailability
- Significantly reduces systolic blood pressure in mice
- Induces dose-dependent diuresis, natriuresis, and kaliuresis
- Reduces blood pressure, stroke volume, and total peripheral resistance; increases heart rate
- Efficacious in rodent models of hypertension and volume overload
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Medchemexpress LLC 17a-Hydroxypregnenolone (17-OHP5) | 387-79-1 | 99.61% | 332.48 | 100 MG
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17a-Hydroxypregnenolone (17-OHP5) is a metabolite of Pregnenolone and a precursor in the biosynthesis of Dehydroepiandrosterone. It acts as a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD). This compound is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and subsequently converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Levels of 17a-hydroxypregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, which is a form of congenital adrenal hyperplasia.
- Metabolite of pregnenolone
- Precursor in dehydroepiandrosterone biosynthesis
- Substrate for 3β-hydroxysteroid dehydrogenase
- Formed by CYP17A1 hydroxylase activity
- Converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity
- Elevated in type II 3β-hydroxysteroid dehydrogenase deficiency
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eMolecules ChemScene / 3-(1H-123-Triazol-1-yl)propanoic acid hydrochloride / 100mg / 711935234 / CS-0160043 / 0.000 / 1803604-38-7 / MFCD27980923 / 177.590 / C5H8ClN3O2
ChemScene / 3-(1H-123-Triazol-1-yl)propanoic acid hydrochloride / 100mg / 711935234 / CS-0160043 / 0.000 / 1803604-38-7 / MFCD27980923 / 177.590 / C5H8ClN3O2
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Enzo Life Sciences Aflatoxin B1 (5mg). CAS: 1162-65-8
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Naturally occuring mycotoxin produced by many species of Aspergillus. Metabolized by the liver to the reactive intermediate aflatoxin M1. Exposure may produce acute necrosis, cirrhosis and carcinoma of the liver. Induces DNA damage. Purity: ≥98% (HPLC, TLC). Solubility: Soluble in DMSO (20mg/ml) or methylene chloride (10mg/ml). Long Term Storage: -20°C.
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Medchemexpress LLC α-Amyrin acetate | 863-76-3 | 5 MG
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α-Amyrin acetate is a pentacyclic triterpenoid compound with oral activity, used in research related to cancer and metabolic diseases such as breast cancer and diabetes.
- Inhibits cancer cell proliferation and induces apoptosis
- Reduces blood glucose levels
- Purity of 99.63%
- White to off-white solid appearance
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eMolecules Medchem Express / STAT5-IN-1 / 5mg / 446257289 / HY-101853 / / 285986-31-4 / MFCD00124694 / 293.282 / C16H11N3O3
Medchem Express / STAT5-IN-1 / 5mg / 446257289 / HY-101853 / / 285986-31-4 / MFCD00124694 / 293.282 / C16H11N3O3
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