Acetylides
Medchemexpress LLC Propargyl-PEG10-acid | 2055022-18-7 | 98.0% | 524.60 | 250 MG
Propargyl-PEG10-acid is a PEG derivative containing a propargyl group with a terminal carboxylic acid. It functions as a click chemistry reagent, utilizing an alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing azide groups.
- PEG derivative
- Contains a propargyl group
- Features a terminal carboxylic acid
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition with azide groups
eMolecules 59608-01-4 | 3-(Pyridin-3-yl)propiolic acid | MFCD02177466 | 1g
Ambeed | 3-(Pyridin-3-yl)propiolic acid | 1g | 588343019 | A625596 | 59608-01-4 | MFCD02177466 | 147.133 | C8H5NO2
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![Medchemexpress LLC Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]- | 944561-44-8 | MFCD19160595 | 99.6% | 143.18 g/mol | C7H13NO2 | 100 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202861.png-250.jpg)
Medchemexpress LLC Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]- | 944561-44-8 | MFCD19160595 | 99.6% | 143.18 g/mol | C7H13NO2 | 100 G
Propargyl-PEG2-amine is a PEG-based bifunctional linker that contains a terminal propargyl (alkyne) group and a primary amine, designed for conjugation chemistry and synthetic applications such as antibody-drug conjugate (ADC) formation, PROTAC assembly, and click chemistry.
- PEG-2 spacer with terminal propargyl group
- Primary amine functional group for conjugation
- High purity suitable for synthesis (99.6%)
- Colorless to light yellow liquid; density 0.992 ± 0.06 g/cm3
- Compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAC)
Medchemexpress LLC Propargyl-PEG5-Br | 1287660-83-6 | 339.22 | 100 MG
Propargyl-PEG5-Br is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Propargyl-PEG9-amine | 2093153-98-9 | 97.0% | 50 MG
Propargyl-PEG9-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with molecules containing Azide groups
Medchemexpress LLC Propargyl-PEG2-NHS ester | 2512228-06-5 | ≥98.0% | 269.25 g/mol | 100 MG
This PEG-based linker is designed for the synthesis of proteolysis-targeting chimeras (PROTACs), which are molecules that utilize the ubiquitin-proteasome system to degrade target proteins. It functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.
- Functions as a linker in targeted protein degradation research.
- Acts as a click chemistry reagent.
- Contains an alkyne functional group for specific reactions.
- Can undergo copper-catalyzed azide-alkyne cycloaddition.
- Enables conjugation with azide-containing molecules.
- Offers high purity for reliable experimental results.
Medchemexpress LLC N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) | 2112732-01-9 | > 96% | 519.58 | 250 MG
N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group, which allows it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Allows copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Sigma Aldrich Fine Chemicals Biosciences 3-Chloro-3-methyl-1-butyne 97% | 1111-97-3 | MFCD00190221 | 25G
3-Chloro-3-methyl-1-butyne 97% | Purity: 97% | Mol Wt: 102.56 | 1111-97-3 | MFCD00190221 | 25G
Medchemexpress LLC Propargyl-PEG8-OH | 1351556-81-4 | 5 G
Propargyl-PEG8-OH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
- Molecular weight: 408.48
- Formula: C19H36O9
- Relevant for cancer and cancer targeted therapy
Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | MFCD30536167 | 98.0% | 392.44 g·mol-1 | C18H32O9 | 50 MG
Propargyl-PEG7-acid is a polyethylene glycol (PEG)-based linker with a terminal propargyl (alkyne) group and a carboxylic acid. It is used as a click-chemistry compatible linker for assembling PROTACs and antibody-drug conjugates, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach payloads or targeting moieties.
- Cleavable PEG linker suitable for PROTAC and ADC synthesis.
- Contains a terminal alkyne for CuAAC (click chemistry) conjugation.
- High purity supports reliable coupling reactions.
- Stable as a dry powder when stored under inert atmosphere at low temperature.
- Available in small research packs for medicinal chemistry use.
eMolecules 106-96-7 | 3-Bromo-1-Propyne(80% wt.in toluene) | AA Blocks LLC | MFCD00000241 | 118.961 | C3H3Br | 0.000 | BrCC#C | 100g | 586018241
3-Bromo-1-Propyne(80% wt.in toluene) | AA Blocks LLC | 106-96-7 | MFCD00000241 | 118.961 | C3H3Br | 0.000 | BrCC#C | 100g | 586018241
(C)C#C | 100g | 267169362](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000225185.jpg-250.jpg)
eMolecules 1066-54-2 | Trimethylsilylacetylene | Combi-Blocks | MFCD00008569 | 98.220 | C5H10Si | 95.000 | C[Si](C)(C)C#C | 100g | 267169362
Trimethylsilylacetylene | Combi-Blocks | 1066-54-2 | MFCD00008569 | 98.220 | C5H10Si | 95.000 | C[Si](C)(C)C#C | 100g | 267169362