Acetylides
Medchemexpress LLC Propargyl-PEG3-methane | 89635-82-5 | MFCD27977518 | 98.0% | 202.25 | 500 MG
Propargyl-PEG3-methane is a PEG-based PROTAC linker, designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It functions as a versatile click chemistry reagent, facilitating various bioconjugation and labeling applications.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Facilitates bioconjugation and labeling
Medchemexpress LLC Propargyl-PEG3-bromide | 203740-63-0 | 97.7% | 251.12 | 1 G
Propargyl-PEG3-bromide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It also functions as a click chemistry reagent, containing an alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that possess azide groups. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Click chemistry
- Alkynes
- PROTAC synthesis
- Disease areas: Cancer, Cancer targeted therapy
- PROTAC linkers
Medchemexpress LLC Propargyl-PEG9-amine | 2093153-98-9 | 97.0% | 25 MG
Propargyl-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Alkyne group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
Medchemexpress LLC N-(Propargyl-PEG4)-biocytin | 2055042-71-0 | 98.0% | C28H46N4O9S | 250 MG
N-(Propargyl-PEG4)-biocytin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs consist of two different ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other the protein of interest, utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Supports targeted protein degradation
Medchemexpress LLC Clodinafop-propargyl | 105512-06-9 | 98.0% | 349.74 | 10MM/1ML
Clodinafop-propargyl is a primary member of aryloxyphenoxy-propionate herbicides, utilized for the postemergence control of annual grasses in cereals. This compound also serves as a click chemistry reagent due to its alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- Used for postemergence control of annual grasses in cereals
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
Medchemexpress LLC Bis-propargyl-PEG6 100mg | 400775-35-1 | 358.43 g·mol⁻¹ | C18H30O7 | 100 MG
Bis-propargyl-PEG6 is a polyethylene glycol (PEG) linker bearing two terminal propargyl (alkyne) groups separated by a six-unit PEG spacer. It supplies clickable alkyne handles for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and is used to build bifunctional molecules such as PROTACs, polymer-linked multimers, and other bioconjugates. Molecular formula C18H30O7; MW 358.43 g·mol⁻1; CAS 400775-35-1.
- Provides two terminal alkyne handles for click chemistry.
- Six-unit PEG spacer improves aqueous solubility and flexibility.
- Well suited for PROTAC linker construction and bioconjugation.
- Compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Typically supplied as a 100 MG package; store at -20 °C for stability.
Matrix Scientific 4-ETHYNYLBENZOIC ACID METHY-1G
4-Ethynylbenzoic acid methyl ester, 97%; 1g,C10H8O2, MFCD00168820, mw 160.17, [3034-86-4]
(C)CC#C | 1g | 290668426](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502447023.PNG-250.jpg)
eMolecules 13361-64-3 | PROPARGYLTRIMETHYLSILANE | AstaTech | MFCD00042922 | 112.247 | C6H12Si | 88.000 | C[Si](C)(C)CC#C | 1g | 290668426
PROPARGYLTRIMETHYLSILANE | AstaTech | 13361-64-3 | MFCD00042922 | 112.247 | C6H12Si | 88.000 | C[Si](C)(C)CC#C | 1g | 290668426
eMolecules 1092460-86-0 | 5-Fluoro-2-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | MFCD11519336 | 210.128 | C8H6F4O2 | 95.000 | OCc1cc(F)ccc1OC(F)(F)F | 1g | 562454462
5-Fluoro-2-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | 1092460-86-0 | MFCD11519336 | 210.128 | C8H6F4O2 | 95.000 | OCc1cc(F)ccc1OC(F)(F)F | 1g | 562454462
Medchemexpress LLC Propargyl-peg6-acid | 1951438-84-8 | 348.39 g/mol | C16H28O8 | 50 MG
Propargyl-PEG6-acid is a PEG6-based linker and click-chemistry reagent containing a terminal propargyl (alkyne) group and a carboxylic acid. It is used to introduce a PEG6 spacer in the synthesis of PROTACs and antibody-drug conjugates (ADCs) and undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation.
- Used as PEG6 spacer in PROTAC and ADC synthesis.
- Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Molecular weight 348.39 g/mol; formula C16H28O8.
- CAS number 1951438-84-8 for unambiguous identification.
- Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Propargyl-PEG1-NH2 100mg | 122116-12-5 | 99.13 g/mol | C5H9NO | 100 MG
Propargyl-PEG1-NH2 is a short polyethylene glycol linker bearing a terminal propargyl (alkyne) group and a primary amine. It is used as a bifunctional coupling handle in medicinal chemistry and bioconjugation workflows, and is compatible with click chemistry for assembling conjugates such as PROTACs.
- Short PEG1 linker with terminal alkyne and primary amine.
- Facilitates copper-catalyzed azide-alkyne cycloaddition (click) conjugations.
- High purity (98.8%) suitable for research and synthetic applications.
- Available in small research pack sizes for rapid screening and synthesis.
- Store at 4°C and protect from light; aliquot prepared solutions to avoid repeated freeze-thaw cycles.
eMolecules 764-37-4 | (E)-Pent-3-en-1-ol | Combi-Blocks, Inc. | MFCD07636756 | 86.134 | C5H10O | 95.000 | C\C=C\CCO | 5g | 854189543
(E)-Pent-3-en-1-ol | Combi-Blocks, Inc. | 764-37-4 | MFCD07636756 | 86.134 | C5H10O | 95.000 | C\C=C\CCO | 5g | 854189543
Selleck Chemical LLC AZ 628 S2746-1g
AZ628 is a new pan-Raf inhibitor for BRAF BRAFV600E and c-Raf-1 with IC50 of 105 nM 34 nM and 29 nM in cell-free assays also inhibits VEGFR2 DDR2 Lyn Flt1 FMS etc AZ628 induces apoptosis