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Medchemexpress LLC Propargyl-PEG1-acid | 55683-37-9 | 97.0% | 5 G
Supplier: Medchemexpress LLC HY1305045G
Propargyl-PEG1-acid is a PEG-based PROTAC linker, utilized in the synthesis of BTK-CRBN PROTACs, including Ibrutinib-based PROTAC 4 and PROTAC 5. PROTAC 5 is known to degrade BTK and induce degradation of CSK, LYN, and LAT2. This compound also functions as a click chemistry reagent, featuring an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. BTK-CRBN PROTACs are stoichiometric degraders, facilitating BTK protein degradation through the recruitment of cereblon E3 ligases.
- Peg-based PROTAC linker
- Used in synthesis of BTK-CRBN PROTACs
- Functions as a click chemistry reagent
- Features an alkyne group for CuAAc reactions
- Degrades BTK protein
- Induces degradation of CSK, LYN, and LAT2
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