Acetylides
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Medchemexpress LLC Propargyl-PEG4-acid | 1415800-32-6 | 97.0% | 1 G
Propargyl-PEG4-acid is a PEG-based PROTAC linker primarily used in the synthesis of BTK-IAP PROTACs. It also functions as a click chemistry reagent, containing an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups. These PROTACs act as stoichiometric degraders, leading to the degradation of BTK protein by recruiting IAP E3 ligases.
- PEG-based PROTAC linker
- Used in the synthesis of BTK-IAP PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group for CuAAc reactions
- Enables degradation of BTK protein
