Hydrochlorides
Sigma Aldrich Fine Chemicals Biosciences Nisoxetine hydrochloride solid, >=98% (HPLC) | 57754-86-6 | MFCD00153850 | 25MG
Nisoxetine hydrochloride solid, >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 307.82 | 57754-86-6 | MFCD00153850 | 25MG
Sigma Aldrich Fine Chemicals Biosciences Nisoxetine hydrochloride solid, >=98% (HPLC) | 57754-86-6 | MFCD00153850 | 100MG
Nisoxetine hydrochloride solid, >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 307.82 | 57754-86-6 | MFCD00153850 | 100MG
Medchemexpress LLC DANP dihydrochloride | 99.3% | 50 MG
DANP dihydrochloride is a bulge base recognition probe that strongly and specifically binds to the single cytosine and thymine bulges. It can stabilize both single cytosine and thymine bulges in duplex DNA.
- Bulge base recognition probe
- Strongly and specifically binds to single cytosine and thymine bulges
- Can stabilize both single cytosine and thymine bulges in duplex DNA
Medchemexpress LLC Duloxetine | 116539-59-4 | 99.9% | 25 MG
Duloxetine, also known as LY248686, is a potent serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM. It is primarily utilized in research for its role in treating major depressive disorder and generalized anxiety disorder (GAD). This compound selectively inhibits the reuptake of serotonin and norepinephrine within the central nervous system, demonstrating less potency in inhibiting dopamine reuptake. It is intended for research use only and not for patient administration.
- Serotonin-norepinephrine reuptake inhibitor
- Used for major depressive disorder research
- Used for generalized anxiety disorder research
- Selective reuptake inhibitor at 5-HT and NA transporters
- No significant affinity for various other receptors (dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, GABA)
Apexbio Technology LLC Tirofiban 144494-65-5 5mg
Tirofiban is a selective non-peptide antagonist targeting platelet glycoprotein (GP) IIb/IIIa receptors a heterodimeric complex abundantly expressed on platelet surfaces responsible for mediating fibrinogen binding and platelet aggregation It acts through competitive inhibition of fibrinogen binding at GP IIb/IIIa sites thereby suppressing platelet cross-linking and aggregation induced by agonists like ADP In vitro studies demonstrate that Tirofiban inhibits ADP-induced platelet aggregation with an IC50 value of approximately 9 nM showing significantly lower affinity for integrin v 3 (vitronectin receptor) Tirofiban is frequently applied in biomedical research investigating platelet aggregation mechanisms and thrombotic events
Medchemexpress LLC 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride | 1123491-15-5 | 99.1% | 339.22 | 10 MG
DMPQ dihydrochloride is a potent and selective inhibitor of human platelet-derived growth factor receptor β (PDGFRβ) with an IC50 of 80 nM. It is for research use only and not sold to patients.
- Potent and selective inhibitor of human PDGFRβ.
Medchemexpress LLC ADL-5859 (hydrochloride) | 850173-95-4 | 99.0% | 25 MG
ADL-5859 hydrochloride is a selective and orally active δ opioid receptor (DOR) agonist with a Ki of 0.84 nM and an EC50 value of 20 nM. It also exhibits inhibitory activity to the hERG channel with an IC50 value of 78 μM. This compound is suitable for pain research.
- Selective and orally active δ opioid receptor (DOR) agonist
- Ki of 0.84 nM and EC50 of 20 nM for δ opioid receptor
- Inhibits hERG channel with IC50 of 78 μM
- Inhibits cytochrome P450 2D6 (CYP2D6) with IC50 of 43 μM
- Suitable for pain research
- Reverses hyperalgesia in the inflamed paw of rats
- Shows antidepressant-like activity in rats
- Appears as a white to off-white solid
- Molecular weight: 428.95
- Chemical formula: C24H29ClN2O3
Medchemexpress LLC Urapidil hydrochloride | 64887-14-5 | 99.9% | 1 ML
Urapidil hydrochloride is an orally active α1-adrenoceptor antagonist and 5-HT1A receptor agonist with blood-brain barrier permeability. It exhibits pIC50 values of 6.13 against α1-adrenoceptor and 4.38 against α2-adrenoceptor, and demonstrates an antihypertensive effect.
- Orally active α1-adrenoceptor antagonist
- 5-HT1A receptor agonist
- Blood-brain barrier permeability
- Exhibits antihypertensive effect
- pIC50 of 6.13 against α1-adrenoceptor
- pIC50 of 4.38 against α2-adrenoceptor
Medchemexpress LLC DANP dihydrochloride | 761401-89-2 | 99.3% | 100 MG
DANP dihydrochloride is a bulge base recognition probe that strongly and specifically binds to single cytosine and thymine bulges.
- Functions as a bulge base recognition probe
- Strongly and specifically binds to single cytosine and thymine bulges
- Can stabilize both single cytosine and thymine bulges in duplex DNA
Medchemexpress LLC Duloxetine | 116539-59-4 | 99.9% | 5 MG
Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM. It is used for the treatment of major depressive disorder and generalized anxiety disorder (GAD). It inhibits the reuptake of serotonin and norepinephrine in the central nervous system and is a less potent inhibitor of dopamine reuptake. Its analgesic properties are attributed to sodium ion channel blockade.
- Selective reuptake inhibitor at 5-HT and NA transporters
- Less potent inhibitor of dopamine reuptake
- No significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors
- Potential to decrease pro-inflammatory cytokine activity and increase anti-inflammatory cytokines
- Analgesic properties for conditions like diabetic neuropathy and fibromyalgia
Medchemexpress LLC Benzenepropanamine, γ-(2-methoxyphenoxy)-N-methyl- | 53179-07-0 | 98.56% | 50 MG
Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. It is an antidepressant and local anesthetic, capable of blocking voltage-gated sodium channels. It is suitable for laboratory research and experimentation in various biological activities.
- Potent and selective inhibitor of noradrenaline transporter (NET)
- Kd of 0.76 nM (NET)
- Antidepressant properties
- Local anesthetic properties
- Blocks voltage-gated sodium channels
Sigma Aldrich Fine Chemicals Biosciences Isopentylamine 98
Isopentylamine is an aliphatic amine that is reported to occur in wine and eggs.
Medchemexpress LLC YNT-185 dihydrochloride | 1804978-82-2 | 99.8% | 688.66 | 25 MG
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist. It demonstrates high selectivity with EC50s of 0.028 μM for OX2R and 2.75 μM for OX1R. This compound has been shown to ameliorate narcolepsy-cataplexy symptoms in mouse models, increasing wakefulness and decreasing NREM sleep time.
- Selective orexin type-2 receptor (OX2R) agonist
- Nonpeptide compound
- EC50 of 0.028 μM for OX2R
- Ameliorates narcolepsy-cataplexy symptoms in mouse models
- Increases wakefulness
- Decreases NREM sleep time
Medchemexpress LLC GW405833 hydrochloride | 1202865-22-2 | 99.6% | 483.82 | 25 MG
GW405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB2) agonist with EC50 and Ki values of 0.65 nM and 3.92 nM for CB2, and 16.1 μM and 4772 nM for CB1. It also acts as a non-competitive CB1 antagonist, achieving its analgesic effect through a CB1 receptor-dependent mechanism. It significantly inhibits the production of cAMP stimulated by Forskolin and inhibits glycolysis by down-regulating HIF-1α, thereby alleviating acute liver failure (ALF). This compound exhibits low-efficacy agonism in spleen membranes and reverse agonist effects in hCB2-CHO cells. It inhibits proliferation of hepatic macrophages, reduces TNF-α and IL-1β expressions, and protects against cell death in ALF models.
- Potent and selective CB2 agonist
- Non-competitive CB1 antagonist
- Inhibits cAMP production
- Alleviates acute liver failure by down-regulating HIF-1α
- Reduces TNF-α and IL-1β expressions