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Meropenem trihydrate is a broad-spectrum carbapenem antibiotic that kills bacteria by inhibiting cell wall synthesis It targets penicillin-binding proteins (PBPs) disrupting peptidoglycan cross-linkage leading to bacterial death Effective against Gram-negative bacteria like Escherichia coli Klebsiella pneumoniae and Enterobacter aerogenes with MIC90 values between 0 03 M and 0 25 M it also inhibits Gram-positive strains like Streptococcus pneumoniae (MIC90 0 015 M) and anaerobic species MIC values are pH-dependent averaging 0 06 M at pH 5 5 and 0 03 M at pH 7 5 Meropenem trihydrate is used in antimicrobial susceptibility testing microbiological studies and research on carbapenem resistance and -lactamase stability
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Meropenem trihydrate (MRP) belongs to the carbapenem group of compounds. It is susceptible to degradation at high temperature and humidity. It is soluble in methanol-water or acetone-water combinations. It is used as an antibacterial agent for treating meningitis and pneumonia.
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VO-Ohpic trihydrate is a highly potent inhibitor of PTEN, with an IC50 of 46±10 nM. It significantly inhibits PTEN activity at low nanomolar concentrations. It is described as an encouragingly specific and potent PTEN inhibitor, and the most potent inhibitor (IC50=35 nM) of PTEN lipid phosphatase activity.
Highly potent PTEN inhibitor
IC50 of 46±10 nM for PTEN
Molecular weight: 415.20
Formula: C12H16N2O11V
Appearance: Solid, light green to green
Soluble in DMSO (≥ 50 mg/mL); insoluble in H2O
Useful for in vitro inhibition studies and in vivo applications in mice
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