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1,1,1-Trifluoroethyl-PEG2-propargyl is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups. This design enables PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Click chemistry reagent with alkyne group
Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Enables selective degradation of target proteins via ubiquitin-proteasome system
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