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Organoaluminum compounds possess direct bonds between carbon and aluminum atoms. Predominantly electrophilic, these compounds typically act as Lewis acids in reactions and play a large role in the field of organometallic chemistry.
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Also available in 1 mg, 2 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes. Purity ≥98%
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Acetoacetic acid sodium salt (CAS 623-58-5) is a prominent ketone body generated during hepatic fatty acid -oxidation In physiological conditions it readily dissociates to yield acetoacetic acid which participates in cellular energy production especially during periods of limited glucose availability Elevated levels of acetoacetic acid sodium have been observed in metabolic disorders such as diabetes mellitus where impaired glucose utilization drives enhanced ketone body synthesis This compound is frequently used in biomedical research to model metabolic imbalances investigate ketone body metabolism and study the pathophysiology of diabetic ketoacidosis
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Acetoacetic acid sodium is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. It can be used to study metabolic diseases, as it leads to triglyceride accumulation in hepatocytes by inhibiting very low density lipoprotein (VLDL) assembly.
Oxidative stress inducer
Affects the antioxidant enzyme system and lipoprotein metabolism
Decreases mRNA expression and activity of SOD, CAT, and GSH-Px
Increases MDA content
Inhibits VLDL assembly
Leads to triglyceride accumulation in hepatocytes
Suitable for studying metabolic diseases
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Acetoacetic acid sodium is an oxidative stress inducer impacting the antioxidant enzyme system and lipoprotein metabolism. It can be utilized in metabolic disease studies, as it induces oxidative stress and inhibits very low-density lipoprotein (VLDL) assembly in hepatocytes.
Decreases mRNA expression and activity of antioxidant enzymes (SOD, CAT, GSH-Px).
Increases malondialdehyde (MDA) content.
Downregulates apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR).
Promotes triglyceride (TG) accumulation in hepatocytes.
Requires fresh preparation due to instability in solutions.
Recommended storage at -80°C under nitrogen.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Acetoacetic acid sodium is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. It can be used to study metabolic diseases. The sodium salt form of the compound is prone to thermal instability.
Induces oxidative stress by decreasing mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)
Increases MDA content
Inhibits very low density lipoprotein (VLDL) assembly
Downregulates apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR)
Leads to triglyceride (TG) accumulation in hepatocytes
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More