Organo-Metalloid Compounds
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Filtered Search Results
Medchemexpress LLC N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid | 2183440-74-4 | 98.1% | C29H55N5O13 | 25 MG
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N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent.
- Can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Utilized in the synthesis of PROTACs.
- Enables selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
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Medchemexpress LLC Bromoacetamido-PEG3-C2-Boc | 1807537-33-2 | C15H28BrNO6 | 1 G
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Bromoacetamido-PEG3-C2-Boc is a PEG-based PROTAC linker that is utilized in the synthesis of PROTACs. PROTACs themselves are small molecules composed of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a protein of interest. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Application: used in the synthesis of PROTACs.
- Mechanism: facilitates the degradation of target proteins via the ubiquitin-proteasome system when incorporated into PROTACs.
- Research use: for research purposes only; not intended for sale to patients.
- Form: liquid (density: 1.252 g/cm3), colorless to light yellow.
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Medchemexpress LLC Azido-PEG3-SSPy | 98.6% | 344.45 g/mol | C13H20N4O3S2 | 50 MG
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Azido-PEG3-SSPy is a cleavable three-unit polyethylene glycol (PEG3) linker that contains an azide functional group and a disulfide-pyridyldithiol (SSPy) moiety; it is designed for bioconjugation and ADC linker synthesis using click chemistry.
- Cleavable PEG3 linker enabling disulfide-mediated release.
- Azide functional group supports CuAAC and SPAAC bioconjugation.
- High purity (98.6%) suitable for research applications.
- Molecular weight 344.45 g/mol and formula C13H20N4O3S2.
- Available as a 50 MG vial and stored per manufacturer recommendations.
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Medchemexpress LLC Ms-PEG5-t-butyl ester | 870487-48-2 | C₁₆H₃₂O₉S | 250 MG
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Ms-PEG5-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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Medchemexpress LLC N-(Amino-PEG3)-N-bis(PEG4-Boc) | 2353409-57-9 | 98.0% | C38H76N2O15 | 100 MG
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N-(Amino-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Applicable in cancer-programmed cell death research
- Connects two different ligands for PROTAC formation
- Targets E3 ubiquitin ligase and protein of interest
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC 2-(2-(2-bromoethoxy)ethoxy)ethyl methanesulfonate | 2702323-73-5 | 95.0% | 291.16 | C7H15BrO5S | 5 MG
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Br-PEG3-MS is a brominated, PEG-based PROTAC linker (methanesulfonate) designed for use in chemical synthesis of PROTACs and other bifunctional molecules. It provides a short PEG3 spacer with a reactive leaving group for conjugation chemistry, enabling efficient formation of linkages between ligands under standard organic conditions. For research use only.
- PEG3 spacer with a terminal bromide and methanesulfonate leaving group.
- Suitable for linker synthesis and nucleophilic substitution reactions.
- High purity (95.0% by NMR) for reliable synthetic performance.
- Low molecular weight facilitates handling in small-scale reactions.
- Available in multiple small pack sizes to support medicinal chemistry workflows.
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CCOCCOCCOCCOCCOC)(OCC)OCC | 1g | 411413972](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183485.JPG-250.jpg)
eMolecules 2243566-42-7 | m-PEG5-triethoxysilane | Broadpharm483.674 | C21H45NO9Si | 96.000 | CCO[Si](CCCNC(=O)CCOCCOCCOCCOCCOC)(OCC)OCC | 1g | 411413972
m-PEG5-triethoxysilane | Broadpharm | 2243566-42-7483.674 | C21H45NO9Si | 96.000 | CCO[Si](CCCNC(=O)CCOCCOCCOCCOCCOC)(OCC)OCC | 1g | 411413972
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Medchemexpress LLC Chloro-PEG5-chloride 1g
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Chloro-PEG5-chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
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Medchemexpress LLC Fmoc-NH-PEG3-CH2CH2COOH | 867062-95-1 | 99.8% | 443.49 g/mol | C24H29NO7 | 5 G
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Fmoc-NH-PEG3-CH2CH2COOH is an Fmoc-protected PEG3-based cleavable linker used for conjugation chemistry in research applications such as antibody-drug conjugates and PROTAC synthesis. It provides a short PEG spacer with an Fmoc-protected amino terminus and a terminal carboxylic acid for coupling reactions.
- High purity suitable for research use.
- PEG3 spacer provides solubility and flexibility.
- Fmoc protection enables standard amine deprotection workflows.
- Terminal carboxylic acid allows amide bond formation.
- Available in multiple pack sizes for synthesis scale-up.
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(C)c1cncs1 | 5g | 256640244](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00128114-256640244.PNG-250.jpg)
eMolecules 79265-36-4 | 5-TRIMETHYLSILANYLTHIAZOLE | AstaTech | MFCD00191506 | 157.310 | C6H11NSSi | 97.000 | C[Si](C)(C)c1cncs1 | 5g | 256640244
5-TRIMETHYLSILANYLTHIAZOLE | AstaTech | 79265-36-4 | MFCD00191506 | 157.310 | C6H11NSSi | 97.000 | C[Si](C)(C)c1cncs1 | 5g | 256640244
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Accela Chembio Inc 2 | 2'-bis(trifluoromethyl)benzidine | 100g | 341-58-2 | MFCD00190155 | 97+% | Shelf Life: 1260 Days | Light Sensitive
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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2 | 2'-bis(trifluoromethyl)benzidine | 100g | 341-58-2 | MFCD00190155 | 97+% | Shelf Life: 1260 Days | Light Sensitive
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Medchemexpress LLC PS-1145 | 431898-65-6 | 99.67% | 322.75 | 100 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM, functioning to block TNFα-induced NF-κB activation by inhibiting IκBα phosphorylation in multiple myeloma (MM) cells. This inhibition is observed in a dose- and time-dependent manner. It also enhances the blockade of NF-κB activation when combined with Dexamethasone, and can inhibit the protective effect of IL-6 against Dexamethasone-induced apoptosis.
- Potent inhibitor of IKK activity.
- Blocks phosphorylation of IκBα.
- Inhibits TNFα-induced NF-κB activation.
- Reduces TNFα-induced intracellular adhesion molecule (ICAM)-1 expression.
- Demonstrates antiproliferative activity against certain human cells.
- Decreases serum levels of specific cytokines in vivo.
- Can block inflammation-induced weight gain during high-fat feeding.
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Medchemexpress LLC AK-778-XXMU | 1227045-76-2 | 99.9% | C22H17ClN2O3 | 25 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. It inhibits the ID2-KDR signaling axis, leading to the down-regulation of downstream angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), while up-regulating the tumor suppressor factor (PTEN). It can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and demonstrates significant cancer-suppressing potency. This compound is used for the study of glioma.
- Potent DNA binding inhibitor 2 (ID2) antagonist
- Inhibits cell migration and invasion of glioma cell lines
- Induces apoptosis
- Demonstrates significant cancer-suppressing potency
- Inhibits ID2-KDR signaling axis
- Down-regulates angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9)
- Up-regulates tumor suppressor factor (PTEN)
- Suitable for the study of glioma
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eMolecules 1503378-02-6 | ChemScene | 7-Methoxy-23-dihydrobenzofuran-3-carboxylic acid | 100mg | 712840997 | CS-0438340 | MFCD26129953 | 194.186 | C10H10O4
Ambeed | 4-Bromo-2-(26-dioxopiperidin-3-yl)isoindoline-13-dione | 250mg | 633418021 | A1215363 | 2093536-12-8 | 337.129 | C13H9BrN2O4
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(OC)c1ccccc1 | 10g | 525102076](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC2039302.JPG-250.jpg)
eMolecules 3027-21-2 | Dimethoxy(methyl)(phenyl)silane | Ambeed | MFCD00008343 | 182.294 | C9H14O2Si | 98 | CO[Si](C)(OC)c1ccccc1 | 10g | 525102076
Ambeed | (S)-2-((2R3R)-3-((S)-1-((3R4S5S)-4-((S)-N3-Dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid | 2mg | 491171472 | A309085 | 745017-94-1 | MFCD25976742 | 731.976 | C39H65N5O8
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