Dimethyl Sulfoxide
Apexbio Technology LLC YM155 781661-94-7 10mM (in 1mL DMSO)
YM155 (Sepantronium Bromide CAS 781661-94-7) is a small-molecule inhibitor targeting survivin the smallest protein member of the inhibitor of apoptosis (IAP) gene family YM155 potently suppresses survivin expression while demonstrating minimal influence on other IAP family members or BCL-2-associated proteins Preclinical research shows YM155 inhibits proliferation and induces apoptosis across various human cancer cell lines including non-small cell lung cancer (NSCLC) melanoma bladder cancer aggressive non-Hodgkin lymphoma triple-negative breast cancer (TNBC) and Wilms tumor models In animal xenograft studies YM155 administration results in tumor regression reduces spontaneous metastasis and notably prolongs survival
Apexbio Technology LLC Batimastat (BB-94)(Synonyms: BB-94, Batimastat, MMP inhibitor BB-94), 10mM (in 1mL DMSO), CAS: 130370-60-4.
Batimastat (BB-94 CAS 130370-60-4) is a synthetic small-molecule inhibitor targeting matrix metalloproteinases (MMPs) Structurally a polypeptide-like analogue of collagen substrates batimastat contains a peptidic backbone and a hydroxamate moiety that binds the catalytic zinc atom of MMPs It inhibits several MMP subtypes markedly including MMP-1 MMP-2 MMP-3 MMP-7 and MMP-9 with reported IC50 values of 3 4 20 6 and 4 nM respectively In preclinical studies batimastat demonstrates inhibitory effects on tumor growth and angiogenesis across various tumor models including ovarian and colon carcinoma xenografts making it relevant for cancer research and therapeutic development
Apexbio Technology LLC Ambrisentan 177036-94-1 10mM (in 1mL DMSO)
Ambrisentan (CAS 177036-94-1) is an orally active selective endothelin receptor antagonist specifically targeting ETA receptors It exhibits strong selectivity towards ETA over ETB receptor subtypes shown by Ki values of approximately 1 nM for recombinant ETA receptors expressed in vitro versus 195 nM for ETB In recombinant human receptor assays using intact cells this selectivity is enhanced with reported Ki values of 0 63 nM (ETA) and 48 7 nM (ETB) Pharmacologically ambrisentan s selective ETA blockade preserves the ETB receptor s intrinsic vasodilatory and endothelin clearance functions making it useful in research involving pulmonary arterial hypertension cerebrovascular conditions and ischemia-reperfusion injury