Dimethyl Sulfoxide
Apexbio Technology LLC BML-277 516480-79-8 10mM (in 1mL DMSO)
BML-277 (CAS 516480-79-8) is a potent ATP-competitive inhibitor of checkpoint kinase 2 (Chk2) with an IC50 of approximately 15 nM and a Ki value of 37 nM Mechanistically BML-277 binds specifically to the ATP-binding site of Chk2 blocking its kinase activity In cellular assays BML-277 demonstrates concentration-dependent protective effects against irradiation-induced apoptosis in T-cells with EC50 values ranging from 3 to 7 6 M Due to its selective Chk2 inhibition BML-277 serves as a valuable reagent in studying DNA damage checkpoint pathways and their roles in cell survival and apoptosis
Apexbio Technology LLC VS-5584 (SB2343) 1246560-33-7 10mM (in 1mL DMSO)
VS-5584 (SB2343 CAS 1246560-33-7) is a purine-based inhibitor targeting the mammalian target of rapamycin (mTOR) and all class I phosphoinositide 3-kinase (PI3K) isoforms (PI3K PI3K PI3K and PI3K ) It functions through ATP-competitive inhibition displaying IC50 values of 37 16 68 25 and 42 nmol/L against mTOR PI3K PI3K PI3K and PI3K respectively Through inhibition of PI3K and mTORC1/2-mediated substrate phosphorylation VS-5584 modulates the PI3K/mTOR signaling pathway frequently dysregulated in cancers In preclinical tumor xenograft studies VS-5584 has demonstrated dose-dependent inhibition of tumor growth and pathway signaling underscoring its utility in oncology research