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Apexbio Technology LLC VS-5584 (SB2343) 1246560-33-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A39275.1
VS-5584 (SB2343 CAS 1246560-33-7) is a purine-based inhibitor targeting the mammalian target of rapamycin (mTOR) and all class I phosphoinositide 3-kinase (PI3K) isoforms (PI3K PI3K PI3K and PI3K ) It functions through ATP-competitive inhibition displaying IC50 values of 37 16 68 25 and 42 nmol/L against mTOR PI3K PI3K PI3K and PI3K respectively Through inhibition of PI3K and mTORC1/2-mediated substrate phosphorylation VS-5584 modulates the PI3K/mTOR signaling pathway frequently dysregulated in cancers In preclinical tumor xenograft studies VS-5584 has demonstrated dose-dependent inhibition of tumor growth and pathway signaling underscoring its utility in oncology research
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