Dimethyl Sulfoxide
Apexbio Technology LLC Santacruzamate A (CAY10683) 1477949-42-0 10mM (in 1mL DMSO)
Santacruzamate A (CAY10683 CAS 1477949-42-0) is a selective histone deacetylase (HDAC) inhibitor originally identified in the marine cyanobacterium cf Symploca sp Its mechanism of action involves targeting HDAC enzymes particularly demonstrating high selectivity towards HDAC2 (IC 0 112 nM) when compared with HDAC6 (IC 433 nM) and minimal potency against HDAC4 (IC 1 M) In cellular assays Santacruzamate A reduces growth of tumor cell lines such as HCT-116 colon cancer cells (GI 28 M) and HuT-78 cutaneous T-cell lymphoma cells (GI 1 3 M) It is valuable in epigenetics and oncology research for selectively modulating HDAC2 activity
Apexbio Technology LLC AZD1208 1204144-28-4 10mM (in 1mL DMSO)
AZD1208 (CAS 1204144-28-4) is a selective orally bioavailable pan-Pim kinase inhibitor targeting Pim-1 Pim-2 and Pim-3 kinases with IC50 values of 0 4 nM 5 nM and 1 9 nM respectively Pim kinases are implicated in proliferative and anti-apoptotic signaling downstream of cytokines and growth factors frequently overexpressed in leukemia and lymphoma In vitro AZD1208 inhibits growth induces cell cycle arrest apoptosis and reduces phosphorylation of the anti-apoptotic protein Bcl-2 in AML cell lines Preclinically this compound suppresses tumor growth in AML xenograft models supporting its current clinical evaluation in AML and solid tumor trials