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Dimethyl Sulfoxide

Dimethyl sulfoxide (DMSO) is an organosulfur compound and polar aprotic solvent. Available in various quantities and reagent grades, DMSO is used as a component in PCR mixes, a reversible cell cycle arrester, a cryoprotectant, a differentiation inducer, etc.

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Apexbio Technology LLC MK-8776 (SCH-900776) 891494-63-6 10mM (in 1mL DMSO)
SDP

MK-8776 (SCH-900776 CAS number 891494-63-6) is a selective small molecule inhibitor targeting the serine/threonine kinase checkpoint kinase 1 (Chk1) Chk1 is involved in detecting DNA damage and regulating DNA replication particularly in stabilizing replication forks during genotoxic stress SCH-900776 selectively inhibits Chk1 activity (IC50 3 nM) over Chk2 and Cdk3 In cellular assays SCH-900776 treatment results in dose-dependent inhibition of Chk1 autophosphorylation at Ser296 accompanied by increased phosphorylation at Ser345 a cellular marker consistent with checkpoint disruption In preclinical models combining SCH-900776 with DNA-damaging agents such as gemcitabine enhances anti-tumor efficacy marking its potential utility in cancer research

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