Dimethyl Sulfoxide
Apexbio Technology LLC EMD638683 1181770-72-8 10mM (in 1mL DMSO)
EMD638683 (CAS 1181770-72-8) is a selective inhibitor of serum- and glucocorticoid-inducible kinases (SGKs) including isoforms SGK1 SGK2 and SGK3 SGK1 regulates key cellular processes such as ion transport survival proliferation and responses to steroid hormones EMD638683 shows inhibitory activity against SGK1 SGK2 and SGK3 (IC50 3 M) significantly reducing SGK-dependent phosphorylation of NDRG1 in vitro It demonstrates limited off-target interactions inhibiting only MSK1 and PRK2 at 1 M while sparing numerous other kinases In cell models EMD638683 influences mitochondrial polarization and caspase activity exhibiting antitumor effects in colorectal tumor cells and antihypertensive activity in vivo
Medchemexpress LLC Cimetidine sulfoxide | 54237-72-8 | 97.0% | C10H16N6OS | 10MG
Cimetidine sulfoxide is the sulfoxide metabolite of cimetidine provided for research and analytical applications (CAS 54237-72-8). Supplied as a research-grade solid, it is used as a reference standard in studies of histamine H2-receptor antagonists, drug metabolism, and analytical method development.
- High-purity reference standard suitable for analytical assays.
- Useful for metabolic and pharmacokinetic studies.
- Available in small milligram pack sizes for research use.
- Documentation available: COA, SDS, and handling instructions.
- Stable solid form for storage and long-term use.
Medchemexpress LLC Cimetidine sulfoxide | 54237-72-8 | 97.0% | 268.35 | 25 MG
Cimetidine sulfoxide is a sulfoxide metabolite of Cimetidine. Cimetidine acts as a histamine H2-receptor antagonist and has potential for treating peptic ulcer disease and upper gastrointestinal hemorrhage. Active transport of Cimetidine across the rat small intestine is observable at lower substrate concentrations. Cimetidine sulfoxide is detected after some incubations, and its enantiomeric composition has been determined in rat urine following Cimetidine administration.
- Histamine H2-receptor antagonist
- Potential for peptic ulcer disease treatment
- Potential for upper gastrointestinal hemorrhage treatment
- Sulfoxide metabolite
- Soluble in various solvents for in vitro and in vivo studies
- Store powder at -20°C for 3 years
- Store in solvent at -80°C for 6 months or -20°C for 1 month
Apexbio Technology LLC SCH 527123 473727-83-2 10mM (in 1mL DMSO)
SCH 527123 (CAS 473727-83-2) is a selective antagonist of chemokine receptor 2 (CXCR2) It inhibits CXCR2-mediated signaling pathways by reducing phosphorylation events within the NF- B MAPK and AKT signaling cascades In colorectal cancer cell lines SCH 527123 suppresses cell growth in a dose-dependent manner with reported IC50 values ranging from approximately 18 to 40 mol/L after a 72-hour treatment Elevated IL-8 expression in cell lines such as HCT116 and Caco2 correlates with decreased sensitivity to SCH 527123 This compound is utilized in research investigating CXCR2 signaling in inflammation and tumor growth