Dimethyl Sulfoxide
Apexbio Technology LLC GM 6001 142880-36-2 10mM (in 1mL DMSO)
GM 6001 (Ilomastat Galardin CAS 142880-36-2) is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) including MMP-1 -2 -3 -8 and -9 with reported Ki values of 0 4 nM 0 5 nM 27 nM 0 1 nM and 0 2 nM respectively MMPs participate in extracellular matrix remodeling and mediate signaling events induced by GPCR agonists through EGFR transactivation GM 6001 suppresses EGFR phosphorylation ERK activation and subsequent DNA synthesis induced by stimuli such as bombesin and lysophosphatidic acid (LPA) Additionally this compound has potential applications in cartilage research facilitating meniscal repair under inflammatory conditions by dampening IL-1-mediated MMP activity
Apexbio Technology LLC AZD7545 252017-04-2 10mM (in 1mL DMSO)
AZD7545 (CAS 252017-04-2) is a selective small molecule inhibitor targeting pyruvate dehydrogenase kinase 2 (PDHK2) PDHK2 negatively regulates the pyruvate dehydrogenase (PDH) enzyme complex which converts pyruvate to acetyl-CoA By inhibiting PDHK2 AZD7545 enhances PDH activity In biochemical assays AZD7545 shows potent inhibition of PDHK2 with an IC50 of 6 4 nM whereas it demonstrates somewhat lower potency against PDHK1 (IC50 36 8 nM) In vivo studies using Zucker (fa/fa) rats indicate that AZD7545 administration significantly elevates PDH activity in liver skeletal muscle and heart tissues Thus AZD7545 is proposed as a research tool or therapeutic candidate for metabolic disorders including type 2 diabetes