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Apexbio Technology LLC AZD7545 252017-04-2 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC B12865.1

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AZD7545 (CAS 252017-04-2) is a selective small molecule inhibitor targeting pyruvate dehydrogenase kinase 2 (PDHK2) PDHK2 negatively regulates the pyruvate dehydrogenase (PDH) enzyme complex which converts pyruvate to acetyl-CoA By inhibiting PDHK2 AZD7545 enhances PDH activity In biochemical assays AZD7545 shows potent inhibition of PDHK2 with an IC50 of 6 4 nM whereas it demonstrates somewhat lower potency against PDHK1 (IC50 36 8 nM) In vivo studies using Zucker (fa/fa) rats indicate that AZD7545 administration significantly elevates PDH activity in liver skeletal muscle and heart tissues Thus AZD7545 is proposed as a research tool or therapeutic candidate for metabolic disorders including type 2 diabetes

Catalog No. 50-000-62107


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