Tetrahydrofuran
Medchemexpress LLC Pelcitoclax | 1619923-36-2 | 99.7% | 1281.85 | 10 MG
Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects. It is for research use only. In vitro, APG-1252 changes to a reactive metabolite named APG-1252-M1, which has remarkable antitumor effects in acute myeloid leukemia. In vivo, Pelcitoclax (APG-1252) treatment inhibits xenograft tumor growth.
- Potent Bcl-2/Bcl-xl inhibitor
- Antineoplastic and pro-apoptotic effects
- Changes to reactive metabolite APG-1252-M1 with antitumor effects in acute myeloid leukemia
- Inhibits xenograft tumor growth in vivo
- Solid appearance
- White to off-white color
Medchemexpress LLC RS 09 | 1449566-36-2 | 99.83% | 691.78 | 10 MG
RS 09 is a peptide mimic of LPS and acts as a TLR4 agonist. It binds to TLR-4 and activates NF-κB, and can function as an adjuvant in vivo to enhance the antigen-specific immune response. This compound has been shown to stimulate TLR-4 and activate NF-κB in HEK-BLUE™-4 cells and induce nuclear translocation of NF-κB and secretion of inflammatory cytokines in RAW264.7 cells.
- Acts as a TLR4 agonist
- Binds to TLR-4 and activates NF-κB
- Enhances antigen-specific immune response in vivo
- Stimulates TLR-4 and activates NF-κB in HEK-BLUE™-4 cells
- Induces nuclear translocation of NF-κB and secretion of inflammatory cytokines in RAW264.7 cells
Medchemexpress LLC Nerigliatin | 1245603-92-2 | 99.9% | 432.43 g/mol | C22H20N6O4 | 10 MG
Nerigliatin is a small-molecule glucokinase activator used for laboratory research into glucose-lowering mechanisms. It has demonstrated glucose-lowering efficacy in preclinical studies but has been associated with peripheral nerve degeneration in reported results. Intended for research use only and not for human or clinical applications.
- Glucokinase activator for glucose-lowering research.
- High purity (99.94%).
- Molecular weight 432.43 g/mol.
- Soluble in DMSO at 100 mg/mL with ultrasonic assistance.
- Available in multiple small-scale solid quantities suitable for lab studies.
- Not intended for clinical or human use; handle with appropriate safety precautions.
![Medchemexpress LLC 2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl boronic acid | 1648843-04-2 | 99.7% | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000234135.png-250.jpg)
Medchemexpress LLC 2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl boronic acid | 1648843-04-2 | 99.7% | 10 MG
SX-682 is an orally bioavailable small-molecule allosteric inhibitor of chemokine receptors CXCR1 and CXCR2 under clinical investigation for oncology indications; it blocks recruitment of myeloid-derived suppressor cells and can enhance T-cell activity.
- Orally bioavailable small-molecule CXCR1/2 inhibitor
- Blocks recruitment of myeloid-derived suppressor cells (MDSCs)
- Enhances T-cell activation and antitumor immune responses
- Demonstrated activity in preclinical tumor models and clinical trials
- Supplied with high purity (typical >99%) and available in small-mass packaging for research
Medchemexpress LLC Specnuezhenide ((8E)-Nuezhenide) | 39011-92-2 | 99.5% | 686.66 g/mol | C31H42O17 | 10 MG
Specnuezhenide is a natural iridoid glycoside isolated from Ligustrum lucidum. It exhibits activity against NF-κB and Wnt/β-catenin signaling and is provided as a high-purity research reagent for in-vitro and analytical applications.
- Natural iridoid glycoside
- Modulates NF-κB and Wnt/β-catenin signaling
- High purity (~99.5%), suitable for analytical and in vitro studies
- Available in small research pack sizes
- Appropriate for biochemical and cell-based assays
Medchemexpress LLC N'-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide | 140405-36-3 | MFCD00542031 | 99.7% | 312.37 g/mol | C17H20N4O2 | 10 MG
RSVA405 (CAS 140405-36-3) is a small-molecule activator of AMP-activated protein kinase (AMPK) used in cellular and biochemical research. It promotes CaMKKβ-dependent AMPK activation, inhibits mTOR signaling, and can induce autophagy; supplied at high purity for research applications.
- Potent AMPK activator; reported EC50 = 1 μM.
- High purity (~99.7%).
- Molecular formula C17H20N4O2; molecular weight 312.37 g/mol.
- Soluble in DMSO; available as solid or DMSO solution.
- For research use only; not for human consumption.
Medchemexpress LLC 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperaz... | 1224964-36-6 | 98.3% | 548.92 | C21H21ClF2N3O8S | 10 MG
XL-784 is a small-molecule selective matrix metalloproteinase (MMP) inhibitor provided for research use. It exhibits potent activity across multiple MMP isoforms and is applied in studies of extracellular matrix remodeling, tumor invasion, and metastasis.
- Selective inhibition of multiple MMPs with reported IC50s in the subnanomolar to micromolar range (e.g., MMP-13 0.56 nM, MMP-2 0.81 nM).
- Suitable for biochemical and cell-based studies of extracellular matrix and cancer biology.
- High purity (98.3%) for reliable experimental outcomes.
- Provided as a solid and as a DMSO solution for flexible dosing.
- Molecular weight 548.92 g/mol; CAS number 1224964-36-6.
![Medchemexpress LLC Urea, N-1,2-dithiolan-4-yl-N'-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]- | 2966536-18-3 | 99.7% | 376.37 g·mol⁻¹ | C14H11F3N2O3S2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000296983.png-250.jpg)
Medchemexpress LLC Urea, N-1,2-dithiolan-4-yl-N'-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]- | 2966536-18-3 | 99.7% | 376.37 g·mol⁻¹ | C14H11F3N2O3S2 | 10 MG
Fast-TRFS is a selective, superfast fluorogenic probe for thioredoxin reductase (TrxR) that produces fluorescence upon reduction of its disulfide bond, enabling rapid imaging of TrxR activity in live cells. It is supplied as a solid or as a 10 mM solution in DMSO and is suitable for cellular imaging and rapid detection assays.
- Selective probe for thioredoxin reductase (TrxR).
- Superfast fluorogenic response upon disulfide reduction.
- Suitable for live-cell imaging of TrxR activity.
- Available as 10 mg solid and 10 mM solution in DMSO.
- High purity (99.7%) and molecular weight 376.37 g·mol⁻¹.
Medchemexpress LLC Taurohyodeoxycholic 10mg | 386523 | 10 MG
Taurohyodeoxycholic acid is a taurine-conjugated 6α-hydroxylated bile acid used in biochemical and preclinical research to investigate liver and intestinal inflammation. It modulates inflammatory markers such as MPO, TNF-α, IL-6, and COX-2, and is applied in models of nonalcoholic fatty liver disease, colitis, and biliary disorders.
- Purity: 99.7%
- Molecular weight: 499.7 g·mol⁻¹
- Chemical formula: C26H45NO6S
- Available as small solid aliquots (for example 10 MG) and as DMSO solution (10 mM x 1 mL)
- Suitable for in vitro assays and in vivo disease models
- Datasheet and SDS available for handling and safety information
Medchemexpress LLC Pelcitoclax | 1619923-36-2 | 99.7% | 1281.85 | 1 ML
Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects. In vitro, APG-1252 changes to the reactive metabolite named APG-1252-M1, which has remarkable antitumor effects in acute myeloid leukemia. Pelcitoclax treatment inhibits xenograft tumor growth more obviously than other groups. In an animal model using BALB/c athymic nude mice, intravenous injection of Pelcitoclax once a day for 10 days inhibited xenograft tumor growth.
Medchemexpress LLC Dalpiciclib 10mg | 1637781-04-4 | 10 MG
Dalpiciclib is an orally active, selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor supplied for research use in a 10 mg vial. It is intended for preclinical and in vitro studies of cell-cycle regulation and anti-tumor activity.
- Selective CDK4/6 inhibitor used in preclinical research.
- Cas 1637781-04-4; molecular formula C25H30N6O2.
- Molecular weight 446.54 g/mol.
- Recommended storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years); in solvent store at -80°C (6 months).
- Soluble in DMSO (50 mg/mL); manufacturer lists in vivo vehicle formulations for dosing.
Medchemexpress LLC 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide | 2095849-04-8 | MFCD31813597 | 98.0% | 479.45 g/mol | C25H20F3N5O2 | 50 MG
CSF1R-IN-1 is a potent small-molecule inhibitor of the colony stimulating factor 1 receptor (CSF1R) with a reported IC50 of 0.5 nM. It shows good intestinal permeability in Caco-2 assays and favorable oral pharmacokinetics in mice. The compound is supplied as a solid for research use and includes standard storage recommendations and available solution formulations.
- Potent CSF1R inhibition (IC50 0.5 nM).
- Molecular formula C25H20F3N5O2; molecular weight 479.45 g/mol.
- High purity (98.04%).
- White to off-white solid physical form.
- Stable storage: powder -20°C for up to 3 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Available in multiple sizes and as a 10 mM solution in DMSO.
2-Methyltetrahydrofuran, Spectrum™ Chemical
CAS: 96-47-9 Molecular Formula: C5H10O Molecular Weight (g/mol): 86.13 InChI Key: JWUJQDFVADABEY-UHFFFAOYNA-N IUPAC Name: 2-methyloxolane SMILES: CC1CCCO1