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A medium-chain unsaturated fatty acid; a precursor in the biosynthesis of the sex pheromone 5(Z)-dodecenal; levels are increased in culture medium from MCF-7 breast cancer cells compared to KMST-6 fibroblasts; plasma levels are increased in the plasma of patients with MCAD deficiency
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Pinolenic acid is a PUFA found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.{14273} Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to EAt.{14280} The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not converted to arachidonic acid metabolically and can reduce arachidonic acid levels in the phosphatidylinositol fraction of Hep-G2 cells from 15.9% to 7.0%.{8724}
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Used in Modified Movat's Stain for connective tissue stains – Elastic tissue stains. See Movat, H.Z.;: Demonstration of all connective tissue elements in a single section. Arch Path., 60:289 – 295, 1955 or Roman N., et al: Orcein-hematoxylin in iodized ferric chloride as a stain for elastic tissue. Stain Technology, 42:199 –202, 1967
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