Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency. This compound offers valuable insights for various research applications.
- Increases presynaptic membrane protein SYN1 in HT22 and rat hippocampal neurons.
- Protects synaptic structure.
- Inhibits the degradation of autophagy marker proteins LC3 and SQSTM1/p62.
- Reduces the formation of autophagosomes.
- Exhibits antidepressant activities in mouse Corticosterone-induced depression models.
- Exhibits neuroprotective activities in mouse Corticosterone-induced depression models.