Organic Acids
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Medchemexpress LLC Ivaltinostat (formic) | 98.3% | 473.56 | 1 MG
Ivaltinostat formic is an orally active, potent pan-HDAC inhibitor that features a hydroxamic acid moiety designed to bind zinc at the catalytic pocket. It inhibits deacetylation of histone H3 and tubulin, inducing p53 accumulation and promoting p53-dependent transactivation. This compound enhances the expression of MDM2 and p21 proteins, increases sensitivity of Gemcitabine-resistant cells to therapies, induces apoptosis, and demonstrates anti-tumour effects.
- Potent pan-HDAC inhibitor
- Inhibits deacetylation of histone H3 and tubulin
- Promotes p53-dependent transactivation
- Enhances expression of MDM2 and p21 proteins
- Increases sensitivity of drug-resistant cells
- Induces apoptosis
- Exhibits anti-tumour effects
- Attenuates oxidative stress and inflammation
