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Organic compounds that contain a carbon atom bonded to a halogen atom, and an oxygen atom via a double bond; commonly derived from an oxoacid by replacing a hydroxyl group with a halogen atom.
Cetrimonium Bromide (CTAB) (CAS 57-09-0) is a cationic surfactant that exerts its biological activity primarily through disruption of microbial membrane integrity via electrostatic interactions with negatively charged membrane components CTAB demonstrates antimicrobial activity by inhibiting microbial growth in in vitro assays Commonly employed in molecular biology protocols CTAB facilitates nucleic acid extraction through cellular lysis precipitation and purification particularly in plant genomic DNA isolation Additionally it is useful for antiseptic formulation studies nanoparticle synthesis and pharmaceutical research including drug delivery system development and stability studies
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Thonzonium Bromide is a surfactant compound identified as an inhibitor of vacuolar ATPase (V-ATPase)-mediated proton transport with an EC50 of approximately 69 M V-ATPase functions as an ATP-dependent proton pump essential for maintaining cellular pH homeostasis by translocating protons across intracellular membranes Investigations show that Thonzonium Bromide disrupts proton translocation without affecting ATP hydrolysis suggesting an uncoupling mechanism of action In cellular studies Thonzonium Bromide reduces cytoplasmic pH levels and inhibits yeast cell growth in a dose-dependent manner It is commonly used as a research tool to study V-ATPase function and to explore cellular processes involving intracellular proton regulation
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Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0 54 nM in HeLa-SURP-luc and CHO-SV40-luc cells does not significantly inhibit SV40 promoter activity but is observed to slightly inhibit the interaction of Survivin with XIAP YM155 down-regulates survivin and XIAP modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells Phase 2
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MitoB bromide is an exomarker of mitochondrial hydrogen peroxide. It is a mitochondria-targeted ratiometric probe that can be used to measure levels of hydrogen peroxide (a major ROS) within living animals. It is rapidly taken up by mitochondria and converts to MitoP, enabling the quantification of H2O2. This product is for research use only.
Exomarker of mitochondrial hydrogen peroxide
Mitochondria-targeted ratiometric probe
Measures levels of hydrogen peroxide in living animals
Rapidly taken up by mitochondria
Enables the quantification of H2O2 by converting to MitoP
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Vecuronium bromide is a non-depolarizing neuromuscular blocking agent. It also functions as a nicotinic acetylcholine receptor (nAChR) inhibitor and a muscle relaxant. This compound can be used for pre-surgical anesthesia and is intended for research use only.