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Organic compounds that are derived from or have a benzene group in their molecular structure. Benzene is an aromatic organic molecule composed of 6 carbon atoms and 6 hydrogen atoms that form a ring. Includes derivatives and substituted molecules.
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A-395 hydrochloride is a small-molecule chemical probe that antagonizes the EED subunit of the Polycomb repressive complex 2 (PRC2). It binds in the H3K27me3-binding pocket of EED, preventing allosteric activation of EZH2 and reducing H3K27 methylation; it shows potent inhibition of the PRC2 complex (reported IC50 ≈ 18 nM). The compound is supplied as the hydrochloride salt and is commonly used in biochemical and cellular studies.
Potent EED antagonist with low-nanomolar PRC2 inhibition.
Prevents allosteric activation of EZH2 and reduces H3K27 methylation.
Validated in structural and biochemical studies for target engagement.
Suitable as a chemical probe for studying PRC2 biology in cells and assays.
Supplied as a hydrochloride salt with good solubility in DMSO.
Available in solution formats for direct use in biochemical assays.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More