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Organic compounds that consists entirely of hydrogen and carbon elements usually organized in a chain; some may have a cyclic structure. Includes hydrocarbons that have additional functional groups such as aromatic rings.
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7-Bromohept-1-yne is a bromoalkyne reagent used in medicinal chemistry as a PROTAC linker for constructing bifunctional degraders such as reported research compounds. It is provided as a research-grade material with supporting analytical documentation for laboratory synthesis and method development.
Bromoalkyne functional group enables chemoselective coupling reactions.
Designed for use as a PROTAC linker in targeted protein degradation synthesis.
High purity appropriate for research applications.
Supplied with a certificate of analysis for analytical traceability.
Suitable for standard laboratory storage and handling when kept under recommended conditions.
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BQR-695 is a PI4KIIIβ inhibitor with IC50s of 80 nM for human PI4KIIIβ and 3.5 nM for the Plasmodium variant of PI4KIIIβ. Treatment with 0.5 μM causes GFP-PHOsh2 to redistribute to the parasite plasma membrane, consistent with depletion of intracellular PI4P upon inhibition of PfPI4K function. This inhibitor shows no evidence of toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest, and exhibits cross-resistance with imidazopyrazine-resistant lines.
Potent PI4KIIIβ inhibitor
Effective against human and Plasmodium PI4KIIIβ variants
Induces schizont-stage arrest
No toxicity against mature red blood cells
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